Results 51 to 60 of about 1,065,082 (380)

High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes

Journal of Experimental Medicine, 2000
Lipopolysaccharide (LPS) is lethal to animals because it activates cytokine release, causing septic shock and tissue injury. Early proinflammatory cytokines (e.g., tumor necrosis factor [TNF] and interleukin [IL]-1) released within the first few hours of
U. Andersson, Haichao Wang, K. Palmblad, A. Aveberger, O. Bloom, H. Erlandsson‐Harris, A. Janson, R. Kokkola, Minghuang Zhang, Huan Yang, K. Tracey   +10 more
semanticscholar   +1 more source

Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts

Journal of Leukocyte Biology, 2020
Clinical evidence indicates that the fatal outcome observed with severe acute respiratory syndrome‐coronavirus‐2 infection often results from alveolar injury that impedes airway capacity and multi‐organ failure—both of which are associated with the ...
Jin Wang, Mengmeng Jiang, Xin Chen, L. Montaner   +3 more
semanticscholar   +1 more source

The Pseudomonas aeruginosa autoinducer 3O-C12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells. [PDF]

PLoS ONE, 2011
The discovery of novel antiinflammatory targets to treat inflammation in the cystic fibrosis (CF) lung stands to benefit patient populations suffering with this disease.
Matthew L Mayer, Jared A Sheridan, Christoph J Blohmke, Stuart E Turvey, Robert E W Hancock   +4 more
doaj   +1 more source

PROTAC targeting cyclophilin A controls virus-induced cytokine storm

iScience, 2023
Summary: Cytokine storms caused by viruses are associated with elevated cytokine levels and uncontrolled inflammatory responses that can lead to acute respiratory distress syndrome. Current antiviral therapies are not sufficient to prevent or treat these
Heqiao Li, Wenxian Yang, Huizi Li, Xiaoyuan Bai, He Zhang, Wenhui Fan, Wenjun Liu, Lei Sun   +7 more
doaj   +1 more source

ProNGF-p75NTR axis plays a proinflammatory role in inflamed joints. A novel pathogenic mechanism in chronic arthritis [PDF]

, 2017
To identify the role of mature nerve growth factor (mNGF), its immature form proNGF and their receptors in arthritis ...
Benedetti, Fabrizio De, Bracci-laudiero, Luisa, Caiello, Ivan, Magni-manzoni, Silvia, Manni, Luigi, Manzo, Antonio, Marafon, Denise Pires, Minnone, Gaetana, Prencipe, Giusi, Soligo, Marzia   +9 more
core   +1 more source

VHH-Based Bispecific Antibodies Targeting Cytokine Production

Frontiers in Immunology, 2017
Proinflammatory cytokines, such as TNF, IL-6, and IL-1, play pathogenic roles in multiple diseases and are attractive targets for biologic drugs. Because proinflammatory cytokines possess non-redundant protective and immunoregulatory functions, their ...
Maxim A. Nosenko, Maxim A. Nosenko, Kamar-Sulu N. Atretkhany, Kamar-Sulu N. Atretkhany, Vladislav V. Mokhonov, Vladislav V. Mokhonov, Grigory A. Efimov, Grigory A. Efimov, Andrey A. Kruglov, Andrey A. Kruglov, Andrey A. Kruglov, Sergei V. Tillib, Sergei V. Tillib, Marina S. Drutskaya, Marina S. Drutskaya, Sergei A. Nedospasov, Sergei A. Nedospasov, Sergei A. Nedospasov, Sergei A. Nedospasov   +18 more
doaj   +1 more source

Cytokines and chemokines as regulators of skeletal muscle inflammation: presenting the case of Duchenne muscular dystrophy [PDF]

, 2013
Duchenne muscular dystrophy is a severe inherited muscle disease that affects 1 in 3500 boys worldwide. Infiltration of skeletal muscle by inflammatory cells is an important facet of disease pathophysiology and is strongly associated with disease ...
De Bleecker, Jan, De Paepe, Boel
core   +3 more sources

Central Proinflammatory Cytokines and Pain Enhancement [PDF]

Neurosignals, 2005
Enhanced pain is a component of the 'sickness response' which is an evolutionarily adaptive constellation of responses that enhance the survival of the host. Proinflammatory cytokines mediate these sickness behaviors, and whether proinflammatory cytokines are involved in exaggerated pain has become an intriguing question.
Julie, Wieseler-Frank, Steven F, Maier, Linda R, Watkins   +2 more
openaire   +2 more sources

Green tea extract supplement reduces D-galactosamine-induced acute liver injury by inhibition of apoptotic and proinflammatory signaling

Journal of Biomedical Science, 2009
Oxidative stress and inflammation contributed to the propagation of acute liver injury (ALI). The present study was undertaken to determine whether D-galactosamine (D-GalN) induces ALI via the mitochondrial apoptosis- and proinflammatory cytokine ...
Lee Hsuan-Shu, Yu Chia-Jung, Chen Wang-Chuan, Lin Bor-Ru, Chang Huei-Min, Lee Yen-Chih, Chien Chiang-Ting, Chen Chau-Fong   +7 more
doaj   +1 more source

Effect of Perceived Stress on Cytokine Production in Healthy College Students [PDF]

, 2015
Chronic psychological stress impairs antibody synthesis following influenza vaccination. Chronic stress also increases circulating levels of proinflammatory cytokines and glucocorticoids in elders and caregivers, which can impair antibody synthesis.
McCarthy, Donna O., Neal, Jeremy L., Sribanditmongkol, Vorachai, Szalacha, Laura A.   +3 more
core   +1 more source