Results 71 to 80 of about 1,065,082 (380)

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

SERCA2 regulates non-CF and CF airway epithelial cell response to ozone. [PDF]

PLoS ONE, 2011
Calcium mobilization can regulate a wide range of essential functions of respiratory epithelium, including ion transport, ciliary beat frequency, and secretion of mucus, all of which are modified in cystic fibrosis (CF).
Shama Ahmad, David P Nichols, Matthew Strand, Raymond C Rancourt, Scott H Randell, Carl W White, Aftab Ahmad   +6 more
doaj   +1 more source

MicroRNA-Regulated Proinflammatory Cytokines in Sarcopenia [PDF]

Mediators of Inflammation, 2016
Sarcopenia has been defined as the aging-related disease with the declined mass, strength, and function of skeletal muscle, which is the major cause of frailty and falls in elders. The activation of inflammatory signal pathways due to diseases and aging is suggested to reveal the critical impact on sarcopenia.
Jingjing Fan, Xianjuan Kou, Yi Yang, Ning Chen   +3 more
openaire   +3 more sources

The MMP‐9/TIMP‐1 Ratio and Concentrations of Osteopontin Are Elevated in Cerebrospinal Fluid of People With Multiple Sclerosis and Decrease After Autologous Hematopoietic Stem Cell Transplantation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the utility of cerebrospinal fluid (CSF) biomarkers—matrix metalloproteinase‐9 (MMP‐9), tissue inhibitor of metalloproteinases‐1 (TIMP‐1), the MMP‐9/TIMP‐1 ratio, and osteopontin (OPN)—as indicators of blood–brain barrier (BBB) integrity and disease activity in people with relapsing–remitting multiple sclerosis (pwMS ...
Ivan Pavlovic, Ida Erngren, Kim Kultima, Anders Larsson, Malin Müller, Anna Wiberg, Joachim Burman   +6 more
wiley   +1 more source

Deficiency in p38β MAPK fails to inhibit cytokine production or protect neurons against inflammatory insult in in vitro and in vivo mouse models. [PDF]

PLoS ONE, 2013
The p38 MAPK pathway plays a key role in regulating the production of proinflammatory cytokines, such as TNFα and IL-1β, in peripheral inflammatory disorders.
Bin Xing, Adam D Bachstetter, Linda J Van Eldik   +2 more
doaj   +1 more source

Immune response of cows fed polyunsaturated fatty acids under high ambient temperatures [PDF]

, 2009
The aim of the experiment was to determine the effects of 2 different fat supplementations on immune functions of dairy cows under high ambient temperatures.
Albenzio, M, Caroprese, M, Entrican, G, Marzano, A, Sevi, A, Wattegedera, S   +5 more
core   +1 more source

Neuropeptide regulation of proinflammatory cytokine responses [PDF]

Journal of Leukocyte Biology, 1998
Abstract Severe traumatic injuries and infections are frequently accompanied by life-threatening shock and are associated with increases in the proinflammatory cytokines, particularly tumor necrosis factor α (TNF-α). The body's first perception of injury is the nociceptive or pain response.
C, Dickerson, B, Undem, B, Bullock, R A, Winchurch   +3 more
openaire   +2 more sources

The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen, Ali Behram Salar, Abdulkadir Ermis, Erkingul Birday, Lutfu Hanoglu, Bayram Ufuk Sakul   +5 more
wiley   +1 more source

2322 Modulation of autophagy in intestinal health and inflammation

Journal of Clinical and Translational Science, 2018
OBJECTIVES/SPECIFIC AIMS: Modulation of autophagy has the potential to treat inflammatory bowel disease (IBD). IBD is characterized by dysregulated inflammatory pathways and a defective intestinal epithelial barrier.
Eliseo Castillo
doaj   +1 more source

Yin and yang of interleukin-17 in host immunity to infection [version 1; referees: 2 approved] [PDF]

, 2017
The interleukin-17 (IL-17) family cytokines, such as IL-17A and IL-17F, play important protective roles in host immune response to a variety of infections such as bacterial, fungal, parasitic, and viral.
Das, Shibali, Khader, Shabaana
core   +3 more sources