Results 251 to 260 of about 5,465,036 (281)

Combination Therapy in Participants With Active Psoriatic Arthritis Using Subcutaneous Guselkumab and Golimumab: Week 24 Results From a Phase 2a, Multicenter, Randomized, Double‐Blind, Proof‐of‐Concept Study

Arthritis &Rheumatology, EarlyView.
Objective To assess guselkumab + golimumab combination therapy versus guselkumab monotherapy in participants with active psoriatic arthritis (PsA) and inadequate response to tumor necrosis factor inhibitors (TNFi‐IR). Methods Adults with active TNFi‐IR PsA (three or more tender/swollen joints) were randomized (2:1) to subcutaneous guselkumab (100 mg) +
Jose U. Scher, Iain B. McInnes, Enrique R. Soriano, Joseph F. Merola, Paul Bird, Vinod Chandran, Edaire Cheng, Elena Reynoso, Warner Chen, Maoji Li, Lianne S. Gensler, Philip J. Mease, Christopher T. Ritchlin   +12 more
wiley   +1 more source

Fluorescent–Magnetic Hybrid Nanoparticles Induce a Dose‐Dependent Increase in Proinflammatory Response in Lung Cells in vitro Correlated with Intracellular Localization

Small, 2010
Iron-platinum nanoparticles embedded in a poly(methacrylic acid) (PMA) polymer shell and fluorescently labeled with the dye ATTO 590 (FePt-PMA-ATTO-2%) are investigated in terms of their intracellular localization in lung cells and potential to induce a ...
Zulqurnain Ali, Barbara Rothen-Rutishauser   +1 more
exaly   +2 more sources

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Neuroimmunological Attenuation of Proinflammatory Responses

Science Signaling, 2000
A delicate balance between pro- and anti-inflammatory responses is critical for host defense and host survival against systemic shock. Borovikova et al . demonstrate that acetylcholine (ACh) can retard the inflammatory response of macrophages.
openaire   +2 more sources

Proinflammatory Response of Chronic Liver Disease

Pakistan Journal of Medical and Health Sciences, 2022
Attempts to assess the indication of fortified pointers CD8and CD28in patients spoiled with HCV and assessment ofIL-12 and IL-13 in serum positions in patients with extraordinary HCV A total of (80) seropositive patients for HCV was assessed for this examination .Patients went to general lab., any serum tests imparted positive for against HCV ...
openaire   +1 more source

Non-proinflammatory and responsive nanoplatforms for targeted treatment of atherosclerosis

Biomaterials, 2017
Atherosclerosis is the leading cause of many fatal cardiovascular and cerebrovascular diseases. Whereas nanomedicines are promising for targeted therapy of atherosclerosis, great challenges remain in development of effective, safe, and translational nanotherapies for its treatment.
Yin, Dou, Yue, Chen, Xiangjun, Zhang, Xiaoqiu, Xu, Yidan, Chen, Jiawei, Guo, Dinglin, Zhang, Ruibing, Wang, Xiaohui, Li, Jianxiang, Zhang   +9 more
openaire   +2 more sources

Bioglass?? Attenuates a Proinflammatory Response in Mouse Peritoneal Endotoxicosis

Shock, 2002
Bioglass is a bioactive, resorbable ceramic particle that was developed to assure binding to living tissues. Bioglass is currently employed to fill osseus defects in oral surgery, and it possesses both unique anti-inflammatory and antimicrobial properties.
John E, Rectenwald, Rebecca M, Minter, Jason J, Rosenberg, Gregory C, Gaines, Sean, Lee, Lyle L, Moldawer   +5 more
openaire   +2 more sources

Propensity to excessive proinflammatory response in chronic Lyme borreliosis

APMIS, 2007
The clinical course of Lyme borreliosis is extremely variable. However, all the clinical manifestations, acute or chronic, are characterized by strong inflammation. Borrelia burgdorferi can induce the production of several proinflammatory and anti‐inflammatory cytokines.
Kai E, Kisand, Tiina, Prükk, Kalle V, Kisand, Siiri-Merike, Lüüs, Irja, Kalbe, Raivo, Uibo   +5 more
openaire   +2 more sources

PPARα attenuates the proinflammatory response in activated mesangial cells

American Journal of Physiology-Renal Physiology, 2009
The activated mesangial cell is an important therapeutic target for the control of glomerulonephritis. The peroxisome proliferator-activated receptor α (PPARα) has attracted considerable attention for its anti-inflammatory effects; however, its roles in the mesangial cells remain unknown.
Keiichi, Kono, Yuji, Kamijo, Kazuhiko, Hora, Kyoko, Takahashi, Makoto, Higuchi, Kendo, Kiyosawa, Hidekazu, Shigematsu, Frank J, Gonzalez, Toshifumi, Aoyama   +8 more
openaire   +2 more sources

[Proinflammatory cytokines in humoral immune response].

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2002
Proinflammatory cytokines secreted by cells involved in inflammatory process play a key role in the regulation of immune responses, both cellular and humoral immune response. Through their influence on T-helper lymphocytes and antigen presenting cells including lymphocytes B, they induce secretion of secondary cytokines and, in cooperation with them ...
A, Pietruczuk, J M, Zajkowska, T, Hermanowska-Szpakowicz   +2 more
openaire   +1 more source

Proinflammatory Cytokines and the Host Response to Cancer

1995
The proinflammatory cytokines IL-lβ and IL-6 and tumor necrosis factor (TNF) are so named because of their intimate involvement in the inflammatory response. IL-lβ and TNF-α are produced by macrophages and activated lymphocytes and mediate host responses to endotoxin and other bacterial products.
openaire   +1 more source