Results 31 to 40 of about 625,964 (267)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Project-based Learning (PBL) in EFL learning: Lesson from Indonesia
Al-Ishlah: Jurnal Pendidikan, 2021 Project-based learning (PBL) has gained popularity in education recently. This teaching method provides opportunities for students to learn independently by doing group works in the form of a project.
Ngadiso Ngadiso +4 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
A Unified Glance at Learning in Project-Based Organizations (PBO) [PDF]
مطالعات مدیریت بهبود و تحول, 2018 Project’s is considered a convenient space for learning, due to the temporary nature of the projects, this learning does not become institutionalized in project-based organizations (PBOs).
Mohammad Hossein Sobhiyah +3 more
doaj +1 more source
Jurnal Inovasi Pendidikan dan Sains, 2023 This class action research aims to determine whether there is an increase increativity and achievement in science learning through Project Based Learning in class VIII D of SMP Negeri 2 Ngemplak semester gasal academic year 20 22/2023.
Hariyanto Dwi Cahyo
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Pengaruh Project-Based Learning terhadap Kemampuan Berpikir Kritis
Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2018 : Geography as a field of study is believed to improve the ability of learners in the ability to think. The purpose of this research is to improve the critical thinking ability of learners through project based learning.
Sularmi Sularmi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source