Results 21 to 30 of about 9,090,705 (261)

The chemfp Project [PDF]

open access: yesJournal of Cheminformatics, 2019
Abstract The chemfp project has had four main goals: (1) promote the FPS format as a text-based exchange format for dense binary cheminformatics fingerprints, (2) develop a high-performance implementation of the BitBound algorithm that could be used as an effective baseline to benchmark new similarity search implementations, (3 ...
openaire   +3 more sources

About - The Digital Story Project

open access: yes, 2014
Document pulled from the Migrant Mothers Project website in November ...
Migrant Mothers Project
core   +1 more source

Philanthropy Project. 1986 Minnesota Foundations List. [PDF]

open access: yes, 1986
Philanthropy Project. (1986). Philanthropy Project. 1986 Minnesota Foundations List..
Philanthropy Project
core  

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Project Whirlwind summary report no. 48, fourth quarter 1956 [PDF]

open access: yes, 2009
Includes: review and problem index, current problems arranged according to field of application, current problems arranged according to the mathematics involved; Whirlwind coding and applications, introduction and progress reports; appendices, systems ...
Project Whirlwind Research Staff
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

From organising as projects to projects as organisations

open access: yesInternational Journal of Project Management, 2008
Nowadays, projects and project management can be found in virtually all organisations. Accordingly, preventing project failure has become increasingly critical. In light of this, attempts have been made to redefine the conceptual bases of project management and to define new avenues for research, development of the field, and practical application.
Molloy, E, van Donk, D
openaire   +3 more sources

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