Results 41 to 50 of about 9,090,705 (261)

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Project Whirlwind summary report no. 50, second quarter 1957 [PDF]

open access: yes, 2009
Includes: review and problem index, current problems arranged according to field of application, current problems arranged according to the mathematics involved; Whirlwind coding and applications, introduction and progress reports; academic, introduction,
Project Whirlwind Research Staff
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

The-SmartH2O-project/models: Models of SmartH2O project

open access: yes, 2017
Models of SmartH2O project <p>This repository contains the SmartH2O agent-based models for the district of <strong>Valencia</strong>, Spain (top folder <code>emivasa</code>) and the district of <strong>Terre di ...
The SmartH2O project
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Arkansas Autumn Project collection

open access: yes, 1976
This collection contains material generated by the Arkansas Autumn ...
Arkansas Autumn Project
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Vargas Project Brochure

open access: yes, 1990
Cover page of Vargas Project brochure with photo of Diego de ...
Vargas Project
core  

PERT with MS Project [PDF]

open access: yes, 2006
Describes how to apply PERT with MS Project software. PERT provides a mechanism to explicitly include uncertainty in task durations in a project plan. It is relatively easy to implement. Describes its limitations.
Pons, D.
core  

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