Results 271 to 280 of about 2,145,568 (356)

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Exploring factors associated with company employee involvement in physical activities with older psychiatric outpatients: a qualitative study. [PDF]

Front Psychiatry
van Kraanen K, Smit J, Sassen B, Deenik J, de Kruif A, Rijks S, de Kock A, Rhebergen D.   +7 more
europepmc   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Formal Education in Leadership and Management for the Practicing Clinician. [PDF]

Rambam Maimonides Med J
Savel RH.
europepmc   +1 more source

COMMUNICATION MANAGEMENT IS CRITICAL FOR PROJECT SUCCESS

, 2010
Ksenija Čulo, Vladimir Skendrović
openalex   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Citizen science powers wetland restoration. [PDF]

Environ Sci Ecotechnol
Cui S, Guo H, Pugliese L, Kragh G, Mena S, Wu S.   +5 more
europepmc   +1 more source

Photochemical Control of Perovskite Crystal Formation at Room Temperature

Advanced Science, EarlyView.
The authors demonstrate how ultraviolet (UV) light can enable the crystallization of two‐dimensional (2D) perovskite crystals that are otherwise difficult to grow using conventional thermal methods. These findings are supplemented with a detailed mechanistic description for the interaction of the UV irradiation with the perovskite precursor components.
Magdalena Breitwieser, Lukas E. Lehner, Julius Feigl, Lukas M. Rescher, Julia Felicitas Schwarz, Felix Mayr, Munise Cobet, Bekele Hailegnaw, Christoph Putz, Clemens Schwarzinger, Markus Clark Scharber, Markus Himmelsbach, Bert Nickel, Stepan Demchyshyn, Martin Kaltenbrunner   +14 more
wiley   +1 more source

How to integrate patient and carer perspectives, methodological rigor, and ethics into biomedical research funding. [PDF]

PLoS Biol
Lichtenberg H, Müller C, Lindeman H, Ali L, Minheere A, van den Eijnden M, Dirnagl U.   +6 more
europepmc   +1 more source

How AI Shapes the Future Landscape of Sustainable Building Design With Climate Change Challenges?

Advanced Science, EarlyView.
This review examines how artificial intelligence reshapes sustainable building design faced with climate change challenges. The authors synthesize existing studies to demonstrate AI's transformative potential across design lifecycle phases from climate‐aware form generation to performance optimization.
Pengyuan Shen, Xiaoni Gao, Shuai Lu, Yi Zhang, Xing Zheng, Matthaios Santamouris   +5 more
wiley   +1 more source