Results 131 to 140 of about 5,354,299 (357)

Web based Recommender Systems and Rating Prediction [PDF]

, 2009
This project implements a recommender system on large dataset of Netflix’s movies. This project also tries to improve recommender systems by incorporating confidence interval and genres of movies. This new approach enhances the performance and quality of
Nguyen, Tho
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Identifying New Knowledge Areas to Strengthen the Project Management Institute (PMI) Framework

Organization, Technology and Management in Construction: An International Journal, 2019
In an increasingly volatile, uncertain, complex and ambiguous (VUCA) world, managers of capital projects are under relentless pressure to consistently meet their performance expectations.
Iyer K. Chandrashekhar, Banerjee Partha S.   +1 more
doaj   +1 more source

Performance evaluation of instrument transformers in power quality measurements: activities and results from 19NRM05 IT4PQ project [PDF]

, 2023
G. Crotti, Palma Sara Letizia, Jan Meyer, Robert Stiegler, Mohamed Agazar, Daniela Istrate, Yeying Chen, Enrico Mohns, H. Cayci, B. Ayhan, Helko E. van den Brom, Francisco J. Rodríguez Muñoz, Paolo Mazza, Daniele Palladini, Mario Luiso, Carmine Landi, Roberto Tinarelli, Alessandro Mingotti   +17 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Costs and benefits of inter-departmental innovation collaboration [PDF]

Inter-departmental innovation collaboration facilitates innovation performance. At the same time, it has been identified as source of increased coordination costs. Using organizational information processing theory, this paper builds and tests hypotheses
Cuijpers, Maarten, Guenter, Hannes, Hussinger, Katrin   +2 more
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A Bayesian Network Model of Megaproject Social Responsibility Behavior and Project Performance: From the Perspective of Resource-Based Theory

Buildings
Megaproject Social Responsibility (MSR) is widely acknowledged as contributing to project performance. However, the effect of Megaproject Social Responsibility Behavior (MSRB) implemented by organizations participating in construction on project ...
Yuhua Wu, Zhao Zhou, Linlin Xie, Bo Xia, Mian Huang   +4 more
doaj   +1 more source

Milk from forage on organic dairy farms [PDF]

, 2013
Milk from forage (MFF) has been used as an indicator of dairy enterprise performance since the 1970s. There is considerable evidence associating MFF with good economic performance. ORC researcher Katharine Leach and intern Gaëlle Feur have been looking
Feur, Gaelle, Leach, Katharine
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source