Results 211 to 220 of about 5,354,299 (357)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Research on the influencing factors of sustainable fundraising in internet medical crowdfunding: based on dramaturgical theory. [PDF]

Front Public Health
Huang Z, Han Z.
europepmc   +1 more source

An exploratory study of the state of practice of performance testing in Java-based open source projects

, 2016
Philipp Leitner, Cor‐Paul Bezemer
openalex   +1 more source

Developing a Program Performance Management Framework for Mixed-use Development in Urban Regeneration Projects [PDF]

, 2011
Lee Kang-Wook, Hwa-Uk Hong, Hee-Dae Park, Seungheon Han   +3 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Machine learning approach for prediction of TBM performance and risk of jamming in Himalayan geology using a cross-project tunnelling database. [PDF]

Sci Rep
Katuwal TB, Panthi KK, Basnet CB.
europepmc   +1 more source

Using project performance to measure effectiveness of quality management system maintenance and practices in construction industry. [PDF]

ScientificWorldJournal, 2014
Leong TK, Zakuan N, Mat Saman MZ, Ariff MS, Tan CS.   +4 more
europepmc   +1 more source

Project performance report

Project performance ...
openaire   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

A Transformer-LSTM Hybrid Detector for OFDM-IM Signal Detection. [PDF]

Entropy (Basel)
Wang L, Tong Z, Wang K, Xie J, Peng X, Li B, Li J, Zeng X, Zhan J, Chen R.   +9 more
europepmc   +1 more source