Results 91 to 100 of about 524,960 (300)

Stability and resource allocation in project planning. [PDF]

The majority of resource-constrained project scheduling efforts assumes perfect information about the scheduling problem to be solved and a static deterministic environment within which the pre-computed baseline schedule is executed.
Herroelen, Willy, Leus, Roel
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Triple-Layer Genetic Algorithm (3LGA) for Project Scheduling and Material Ordering Problem with Limited Storage Space

Buildings
Efficient project management in the construction industry depends on optimizing project scheduling and material ordering, two interdependent processes that significantly impact both costs and durations.
Suphawut Malaikrisanachalee, Narongrit Wongwai, Pongpan Promchun   +2 more
doaj   +1 more source

Visualizing the demand for various resources as a function of the master surgery schedule: A case study. [PDF]

Case studies; Demand; Problems; Project scheduling; Scheduling; Studies;
Belien, Jeroen, Cardoen, Brecht, Demeulemeester, Erik   +2 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Software Project Scheduling Problem: A Review

مهندسی مخابرات جنوب
The software project scheduling problem (SPSP) is one of the most important activities in software project development. One of the main reasons for unsuccessful software project completion is non-compliance with cost and schedule plans, often due to ...
Javad Pashaei Barbin, Mahdi Jalali
doaj  

Scheduling of Empennage Structure Design Project of Indonesia’s Aircraft with Critical Path Method (CPM)

MATEC Web of Conferences, 2018
Production of the aircraft becomes very important to facilitate many passengers of aircraft in Indonesia in the future. The design of a very complex aircraft requires proper project management.
Wulandari Arin, Dachyar M., Farizal
doaj   +1 more source

Mathematical formalization of project scheduling problems

Труды Института системного программирования РАН, 2018
Theory of scheduling and project planning is widely applied in diverse scientific and industrial areas. To effectively solve application-specific problems it is necessary to take into account a lot of factors such as task execution models, precedence ...
A. S. Anichkin, V. A. Semenov
doaj   +1 more source

A classification of predictive-reactive project scheduling procedures. [PDF]

The vast majority of the project scheduling research efforts over the past several years have concentrated on the development of workable predictive baseline schedules, assuming complete information and a static and deterministic environment.
Demeulemeester, Erik, Herroelen, Willy, Van de Vonder, Stijn   +2 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source