Results 71 to 80 of about 524,960 (300)

Penyelesaian Permasalahan Penjadwalan Aktivitas Proyek dengan Batasan Sumber Daya Menggunakan Metode Cross Entropy

open access: yesDinamika Rekayasa, 2014
Project scheduling is essential to be planned before activities. Standard methods of project scheduling based on precedence constraints scheduling events and the assumption that resources are not unlimited capacity.
Maria Krisnawati
doaj  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Static scheduling in consideration of resource categories in collaborative product development project

open access: yesAdvances in Mechanical Engineering, 2015
In collaborative product development project plan phase, a reasonable allocation plan can shorten project duration. Static scheduling is a useful way to obtain the allocation result.
Yingzi Li, Shuo Zhang
doaj   +1 more source

Solution and quality robust project scheduling: a methodological framework. [PDF]

open access: yes
The vast majority of the research efforts in project scheduling over the past several years has concentrated on the development of exact and suboptimal procedures for the generation of a baseline schedule assuming complete information and a deterministic
Herroelen, Willy, Leus, Roel
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

A fuzzy pert approach to evaluate plant construction project scheduling risk under uncertain resources capacity

open access: yesJournal of Industrial Engineering and Management, 2009
A plant construction project always involves lots of activities. Precise information about the activities duration is unfortunately unavailable due to the uncertain resources capacity.
Hsian Jong Hsiau, Chun Wei R. Lin
doaj   +1 more source

A multi-agent system with application in project scheduling [PDF]

open access: yes
The new economic and social dynamics increase project complexity and makes scheduling problems more difficult, therefore scheduling requires more versatile solutions as Multi Agent Systems (MAS).
Constanța Nicoleta BODEA   +2 more
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

CONTRIBUTIONS TO MULTI-AGENT SYSTEMS IMPLEMENTATION FOR PROJECT SCHEDULING [PDF]

open access: yes
Increasing project complexity makes scheduling problems more difficult to solve and requires more versatile algorithms. Two different approaches for the project scheduling optimization could be considered: TCPSP (Time-Constrained Project Scheduling), and
Constanta Nicoleta BODEA   +1 more
core  

Home - About - Disclaimer - Privacy