Results 81 to 90 of about 524,960 (300)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

SCHEDULING ANALYSIS BEDUGUL VILLA CONSTRUCTION PROJECT USING PERT AND CPM METHODS

Barekeng
Scheduling in construction projects is necessary so that the planned time to complete the project can be achieved on time. the methods used in optimizing project scheduling are the Project Evaluation Review Technique (PERT) method and the Critical Path ...
Kiswara Agung Santoso, Ade Ratna Yusnita, Agustina Pradjaningsih   +2 more
doaj   +1 more source

A solution procedure for preemptive multi-mode project scheduling problem with mode changeability to resumption

Applied Computing and Informatics, 2018
Extensive research has been devoted to the multi-mode resource constrained project scheduling problem (MRCPSP). However, little attention has been paid to problems where preemption is allowed.
Behrouz Afshar-Nadjafi
doaj   +1 more source

A real options approach to project management. [PDF]

When scheduling an uncertain project, project management may wait for additional (future) information to serve as the basis for rescheduling the project.
Boute, Robert, Demeulemeester, Erik, Herroelen, Willy   +2 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Analysis of Scheduling Method in Building Projects: A Case of Line of Balance and Precedence Diagram Method

Media Komunikasi Teknik Sipil
The construction industry plays a significant role in a country's economic growth. However, construction projects frequently face challenges in meeting schedule targets. Project scheduling is crucial as it provides insights into enhancing the development
Rosmariani Arifuddin, Andi Nurul Fatimah, Muh Rifan Fadlillah   +2 more
doaj   +1 more source

Heuristic procedures for reactive project scheduling. [PDF]

This paper describes new heuristic reactive project scheduling procedures that may be used to repair resource-constrained roject baseline schedules that suer from multiple activity duration disruptions during project execution.The objective is to ...
Ballestin, F, Demeulemeester, Erik, Herroelen, Willy, Van de Vonder, S   +3 more
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Fuzzy goal programming approach for multi-objective multi-mode resource constrained project scheduling problem

KKU Engineering Journal, 2014
This research proposes fuzzy goal programming model for multi-objective multi-mode resource constrained project scheduling problem. Objectives of the problem are minimization of the total time and the total cost of the project.
Busaba Phruksaphanrat, Saran Jarernsuk
doaj  

Optimasi Biaya dan Waktu dalam Penyusunan Jadwal Pelaksanaan Proyek (Studi Kasus Proyek Pembangunan Gedung Pusat Kegiatan Mahasiswa Universitas Diponegoro Semarang)

Media Komunikasi Teknik Sipil, 2015
Execution of conctruction project executed to pass selected project management system from planning phase until operation phase. Unfavorable scheduling system can cause the project to be inefficient.
Dadiyono Amat Pawiro
doaj   +1 more source