Results 101 to 110 of about 522,245 (300)

Project resources leveling using software agents [PDF]

open access: yes
Different approaches to project planning and scheduling have been developed. The Operational Research (OR) approach provides two major planning techniques: CPM and PERT. Artificial Intelligence (AI) initially promoted the automatic planner concept.
BODEA Constanta-Nicoleta, SABAU Mirela
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Project Scheduling Problem

open access: yesXIKUA Boletín Científico de la Escuela Superior de Tlahuelilpan, 2013
Con base en la definición de PSP que se presenta en, las siglas PSP son consideradas como un nombre genérico para toda clase de problemas en los que es necesario programar, de manera óptima el tiempo, costo y los recursos de los proyectos.
openaire   +2 more sources

A real options approach to project management. [PDF]

open access: yes
When scheduling an uncertain project, project management may wait for additional (future) information to serve as the basis for rescheduling the project.
Boute, Robert   +2 more
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

A study of project planning on Libyan construction projects [PDF]

open access: yes, 2008
Construction projects are regularly faced by scheduling problems causing the projects to finish beyond their predetermined due date; this is a global phenomenon.
Abubaker, Ali   +2 more
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

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