Results 61 to 70 of about 522,245 (300)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

CONTRIBUTIONS TO MULTI-AGENT SYSTEMS IMPLEMENTATION FOR PROJECT SCHEDULING [PDF]

Increasing project complexity makes scheduling problems more difficult to solve and requires more versatile algorithms. Two different approaches for the project scheduling optimization could be considered: TCPSP (Time-Constrained Project Scheduling), and
Constanta Nicoleta BODEA, Ileana Ruxandra BADEA   +1 more
core  

Tropical optimization problems in time-constrained project scheduling [PDF]

, 2016
We consider a project that consists of activities to be performed in parallel under various temporal constraints, which include start-start, start-finish and finish-start precedence relationships, release times, deadlines, and due dates.
Krivulin, N.
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

SCHEDULING ANALYSIS BEDUGUL VILLA CONSTRUCTION PROJECT USING PERT AND CPM METHODS

Barekeng
Scheduling in construction projects is necessary so that the planned time to complete the project can be achieved on time. the methods used in optimizing project scheduling are the Project Evaluation Review Technique (PERT) method and the Critical Path ...
Kiswara Agung Santoso, Ade Ratna Yusnita, Agustina Pradjaningsih   +2 more
doaj   +1 more source

A solution procedure for preemptive multi-mode project scheduling problem with mode changeability to resumption

Applied Computing and Informatics, 2018
Extensive research has been devoted to the multi-mode resource constrained project scheduling problem (MRCPSP). However, little attention has been paid to problems where preemption is allowed.
Behrouz Afshar-Nadjafi
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Fuzzy goal programming approach for multi-objective multi-mode resource constrained project scheduling problem

KKU Engineering Journal, 2014
This research proposes fuzzy goal programming model for multi-objective multi-mode resource constrained project scheduling problem. Objectives of the problem are minimization of the total time and the total cost of the project.
Busaba Phruksaphanrat, Saran Jarernsuk
doaj  

Analysis of Scheduling Method in Building Projects: A Case of Line of Balance and Precedence Diagram Method

Media Komunikasi Teknik Sipil
The construction industry plays a significant role in a country's economic growth. However, construction projects frequently face challenges in meeting schedule targets. Project scheduling is crucial as it provides insights into enhancing the development
Rosmariani Arifuddin, Andi Nurul Fatimah, Muh Rifan Fadlillah   +2 more
doaj   +1 more source

Solution and quality robust project scheduling: a methodological framework. [PDF]

The vast majority of the research efforts in project scheduling over the past several years has concentrated on the development of exact and suboptimal procedures for the generation of a baseline schedule assuming complete information and a deterministic
Herroelen, Willy, Leus, Roel
core