Results 61 to 70 of about 1,363,756 (217)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Prediction of SMEs' R&D performances by machine learning for project selection. [PDF]
Sci Rep, 2023 Yoo HS, Jung YL, Jun SP.
europepmc +1 more source
Selection of Project Managers: An Overview
Business Systems Research, 2020 Background: The project manager choice is one of the most important, complicated and multi-layered decisions in project management. Although the competence of a project manager is the subject of numerous studies, mostly in the field of economic sciences,
Kuliš Marija Šiško
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
A decision support process for the selection of sustainable public ICT project investments
International Journal of Information Systems and Project ManagementThe allocation of limited public resources to public investments necessitates selecting projects with the highest social and economic value, along with the greatest likelihood of success.
Muhammed Rasit Ozdas +3 more
doaj +1 more source
Project external environmental factors affecting project delivery systems selection
Journal of Civil Engineering and Management, 2019 Project delivery systems (PDSs) selection is crucial to construction project management success. The matching between construction projects and PDSs is hypersensitive to project external environment.
Bingsheng Liu +4 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Methodological Aspects of Project Techniques Selection for Innovation Project Management
International Journal of Innovation, 2014 Project Management offers a variety of methodologies which provides managers with different techniques and tools to use during project planning and implementation.
Anna Yakovleva
doaj +1 more source