Results 71 to 80 of about 1,391,169 (305)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A scenario based project portfolio selection [PDF]

open access: yesManagement Science Letters, 2015
One of the primary assumptions in many project portfolio selection is the availability of all parameters. However, in real-world cases, many parameters are under uncertainty and the exact values are unknown in advance.
Kamran Pourahmadi   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Project Portfolio Selection with the Maximization of Net Present Value [PDF]

open access: yesJournal of Optimization in Industrial Engineering, 2013
Projects scheduling by the project portfolio selection, something that has its own complexity and its flexibility, can create different composition of the project portfolio.
Mostafa Nikkhah Nasab, Amir Abbas Najafi
doaj  

Evolutionary projection selection for Radon barcodes [PDF]

open access: yes2016 IEEE Congress on Evolutionary Computation (CEC), 2016
To appear in proceedings of The 2016 IEEE Congress on Evolutionary Computation (IEEE CEC 2016), July 24-29, 2016, Vancouver ...
Hamid R. Tizhoosh, Shahryar Rahnamayan
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

A state-of-art survey on project selection using MCDM techniques [PDF]

open access: yesJournal of Project Management, 2017
Project selection is considered as the first essential part of project portfolio management. Project selection is also considered as a process to evaluate each project idea and chooses the one with the biggest priority.
Soheil Sadi-Nezhad
doaj   +1 more source

A benchmark study on the effectiveness of search-based data selection and feature selection for cross project defect prediction [PDF]

open access: yes, 2017
Context: Previous studies have shown that steered training data or dataset selection can lead to better performance for cross project defect prediction(CPDP). On the other hand, feature selection and data quality are issues to consider in CPDP.Objective:
Seyedrebvar Hosseini   +5 more
core   +1 more source

Belgacom: IT Project Selection 2005

open access: yesCommunications of the Association for Information Systems, 2007
This teaching case features a situation at Belgacom, the leading telecommunications company in Belgium, end of April 2005. Wim Bouckenooghe, newly appointed finance director of Belgacom’s Network and IT division within the Fixed Line Services (FLS) segment, is troubled by the effectiveness of the selection of the discretionary IT projects, particularly
Stijn Viaene   +2 more
openaire   +2 more sources

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