Results 31 to 40 of about 615,778 (249)
Atmosphere, 2020 Fortunately, extreme temperatures reaching 50 °C are not common on our planet. The capability of the consortium for small-scale modelling regional climate model (COSMO-CLM), with 0.44° resolution, to project future trends of an extremely hot environment ...
Yoav Levi, Yossi Mann
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ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
FEBS Letters, EarlyView.Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source
Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells
FEBS Letters, EarlyView.Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan +2 more
wiley +1 more source
Ideals of Projections According to σ-Algebras and Unbounded Measurements
Axioms, 2023 A theory of unbounded measures is constructed based on the quantum logics of orthogonal projections. As an analogue of the ring of sets, the projector ideal is proposed. Finite and maximal measures regarding the projector ideals are described.
Marjan Matvejchuk
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FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
Consolidation of the subjects of the Russian Federation as an element of economic development [PDF]
Экономика региона, 2011 The discussion on the optimality of the currently existing structure of the subjects of the Russian Federation is illustrating the contradictions that have been accumulated in the dominion form of government of our country in recent years. In this paper,
Lev Aleksandrovich Korshunov +1 more
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FEBS Letters, EarlyView.Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki +4 more
wiley +1 more source
Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment
FEBS Letters, EarlyView.The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke +2 more
wiley +1 more source
New Estimates of Numerical Values Related to a Simplex
Моделирование и анализ информационных систем, 2017 Let \(n\in {\mathbb N}\) and \(Q_n=[0,1]^n\). For a nondegenerate simplex \(S\subset {\mathbb R}^n\), by \(\sigma S\) we denote the homothetic copy of~\(S\) with center of homothety in the center of gravity of \(S\) and ratio of~homothety \(\sigma\). By
Mikhail V. Nevskii, Alexey Yu. Ukhalov
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