Results 131 to 140 of about 11,611,558 (295)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Human Interest Story Show Disc [Projection]
, 2010 The Theatre and Dance Platform holds a digital copy of the video file (MP4) stored on DVD (show disc) in the Lucy Guerin Inc collection.Projection for Lucy Guerin's Human Interest Story. Projection features news anchor Anton Enus reading a series of news
Lucy Guerin Inc
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
, 2012 Microarray image gridding is one important step of microarray image analysis to determine 2D image coordinates of all array spots in the hybridized gene chip image.
Liu J(刘军) +3 more
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Generalized relaxed alternating projection method [PDF]
, 2011 W artykule przedstawiono różne modyfikacje metody rzutowania naprzemiennego (alternating projection method), wprowadzonej przez von Neumanna. Metody te służą do wyznaczania punktu ze zbioru A i punktu ze zbioru B takich, że jest odległością między ...
Dylewski, R.
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Adaptive Binocular Fringe Dynamic Projection Method for High Dynamic Range Measurement. [PDF]
Sensors (Basel), 2019 Yu C, Ji F, Xue J, Wang Y.
europepmc +1 more source