Results 121 to 130 of about 12,336,647 (296)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
A Local Instrumental Variable Estimation Method for Generalized Additive Volatility Models [PDF]
We investigate a new separable nonparametric model for time series, which includes many ARCH models and AR models already discussed in the literature.
Woocheol Kim, Oliver Linton
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Transcranial photoacoustic computed tomography based on a layered back-projection method. [PDF]
Photoacoustics, 2020 Na S +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
ComputersThe structure and memory organization of graphics processor units (GPUs) manufactured by NVIDIA and the use of CUDA programming technology to solve computational fluid dynamics (CFD) problems is reviewed and discussed.
Redha Benhadj-Djilali +2 more
doaj +1 more source
Projection method as a probe for multiplexing/demultiplexing of magnetically enriched biological tissues. [PDF]
RSC Adv, 2020 Zamani Kouhpanji MR, Stadler BJH.
europepmc +1 more source