Results 101 to 110 of about 11,611,558 (295)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Comparison of two approaches to compute magnetic field in problems with random domains [PDF]

open access: yes, 2012
This paper is a postprint of a paper submitted to and accepted for publication in Science, Measurement & Technology, IET and is subject to Institution of Engineering and Technology Copyright.
MAC, Duy Hung   +2 more
core   +1 more source

Modelling of Lattices of Two-Dimensional Quasi-Crystals

open access: yesУспехи физики металлов, 2019
We propose the method for modelling of quasi-periodic structures based on an algorithm being a geometrical interpretation of the Fibonacci-type numerical sequences.
V. V. Girzhon, O. V. Smolyakov
doaj   +1 more source

Numerical study on aerodynamic effects in passive pitching dynamics of insect flapping wings

open access: yesNihon Kikai Gakkai ronbunshu, 2014
This study is concerned with aerodynamic effects in passive pitching dynamics of insect flapping wings, which would be based on the Fluid-Structure Interaction (FSI). Thus, we evaluated them using three-dimensional numerical analyses for the FSI based on
Daisuke ISHIHARA   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Methods of Projection [PDF]

open access: yes, 2018
Dimensionality reduction techniques reduce the dimensions of the input space to facilitate the exploration of structures in high-dimensional data. Two general dimensionality reduction approaches exist: manifold learning and projection. Manifold-learning methods attempt to find a sub-space in which the high-dimensional distances can be preserved.
openaire   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

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