Results 51 to 60 of about 11,611,558 (295)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Interactive data exploration with targeted projection pursuit [PDF]
, 2009 Data exploration is a vital, but little considered, part of the scientific process; but few visualisation tools can cope with truly complex data. Targeted Projection Pursuit (TPP) is an interactive data exploration technique that provides an intuitive ...
Faith, Joe
core
Strong Convergent Theorems Governed by Pseudo-Monotone Mappings
Mathematics, 2020 The purpose of this paper is to introduce two different kinds of iterative algorithms with inertial effects for solving variational inequalities. The iterative processes are based on the extragradient method, the Mann-type method and the viscosity method.
Liya Liu, Xiaolong Qin, Jen-Chih Yao
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
A Projection Method for Particle Resampling
Computer Physics CommunicationsParticle discretizations of partial differential equations are advantageous for high-dimensional kinetic models in phase space due to their better scalability than continuum approaches with respect to dimension. Complex processes collectively referred to as particle noise hamper long time simulations with particle methods.
Mark F. Adams +3 more
openaire +3 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Физика волновых процессов и радиотехнические системы, 2014 The mathematical simulation of diffraction of TEM-wave on the periodic 2D structures of graphene micro-ribbons with finite length is performed using the computational algorithm developed by projection method for the normal incident TEM-wave at terahertz ...
G.S. Makeeva +2 more
doaj
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Application of a Projection Method for Simulating Flow of a Shear-Thinning Fluid
Fluids, 2019 In this paper, a first-order projection method is used to solve the Navier−Stokes equations numerically for a time-dependent incompressible fluid inside a three-dimensional (3-D) lid-driven cavity. The flow structure in a cavity of aspect ratio
Masoud Jabbari +3 more
doaj +1 more source