Results 101 to 110 of about 4,040,382 (312)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Real minimal hypersurfaces in a complex projective space

open access: yes, 1980
A characterization of the geodesic minimal hypersphere in a complex projective space is given.
Masahiro Kon
core   +1 more source

Bounds on Fake Weighted Projective Space [PDF]

open access: yes, 2009
A fake weighted projective space X is a Q-factorial toric variety with Picard number one. As with weighted projective space, X comes equipped with a set of weights (\lambda_0,...,\lambda_n).
Kasprzyk, Alexander M.   +1 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

The Chemical Space Project

open access: yesAccounts of Chemical Research, 2015
One of the simplest questions that can be asked about molecular diversity is how many organic molecules are possible in total? To answer this question, my research group has computationally enumerated all possible organic molecules up to a certain size to gain an unbiased insight into the entire chemical space. Our latest database, GDB-17, contains 166.
openaire   +4 more sources

Kahler manifolds and their relatives [PDF]

open access: yes, 2010
Let M1 and M2 be two K¨ahler manifolds. We call M1 and M2 relatives if they share a non-trivial K¨ahler submanifold S, namely, if there exist two holomorphic and isometric immersions (K¨ahler immersions) h1 : S → M1 and h2 : S → M2. Moreover, two K¨ahler
Loi, A., Di Scala, Antonio Jose'
core  

Stable hypersurfaces in the complex projective space

open access: yes, 2020
We characterize the sphere with radius tan 2r= 2 n+ 1 in the complex projective space CPn as the unique stable hypersurface subject to certain bounds on the ...
Righini A., Battaglia E., Monti R.
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

A Projective Closure and Projective Horizon of an Affine Space

open access: yes, 2008
Summary. With every affine space A we correlate two incidence structures. The first, called Inc-ProjSp(A), is the usual projective closure of A, i.e. the structure obtained from A by adding directions of lines and planes of A.
Henryk Oryszczyszyn
core  

Home - About - Disclaimer - Privacy