Results 111 to 120 of about 8,504,062 (361)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
The block structure spaces of real projective spaces and orthogonal calculus of functors
, 2006 Given a compact manifold X, the set of simple manifold structures on X x \Delta^k relative to the boundary can be viewed as the k-th homotopy group of a space \S^s (X). This space is called the block structure space of X.
Macko, Tibor
core
Projective product spaces [PDF]
Journal of Topology, 2010 One theorem, which originally asserted homotopy equivalence, has been improved to now assert ...
openaire +3 more sources
Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source
Molecular Oncology, EarlyView.In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella +18 more
wiley +1 more source
Projections of Banach spaces [PDF]
Proceedings of the American Mathematical Society, 1972 For we take X=m, E=co in the Lemma. REMARKS. 1. The method of [4] is to find a hereditary property of m which m/cO does not have. We found a nonhereditrary property preserved under projection. 2. An easy extension is available. All we used about the projection is that it is bounded and has a bounded right inverse Q.
openaire +2 more sources
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation
Molecular Oncology, EarlyView.Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban +12 more
wiley +1 more source
On geometry of orbits of adapted projective frame space
Дифференциальная геометрия многообразий фигур, 2019 The current paper continues consideration of geometry of projective frame orbits started in the author’s article in the previous issue. The n-dimensional projective space with a distinguished point (the center) is considered.
A. Kuleshov
doaj +1 more source