Results 11 to 20 of about 19,767 (298)

Prolactinomas [PDF]

JAMA, 2021
Hyperprolactinemia, defined by a level of serum prolactin above the standard upper limit of normal range, is a common finding in clinical practice and prolactinomas are the main pathological cause. Prolactinomas lead to signs and symptoms of hormone oversecretion, such as galactorrhea and hypogonadism, as well as symptoms of mass effect, including ...
Pauline P, Huynh, Lisa E, Ishii, Masaru, Ishii   +2 more
openaire   +4 more sources

Transcriptomic analysis of the anti-tumor effects of leflunomide in prolactinoma [PDF]

Scientific Reports
Leflunomide’s anti-tumor effects have been investigated in various types of tumors; however, its impact on pituitary adenoma, particularly prolactinoma, is unclear.
Xiangdong Pei, Yuyang Peng, Huachun Yin, Zhenle Zang, Kaifeng Shen, Song Li, Chunqing Zhang   +6 more
doaj   +2 more sources

Cholesterol-activated stress granules reduce the membrane localization of DRD2 and promote prolactinoma dopamine agonists resistance [PDF]

Acta Neuropathologica Communications
Prolactinoma is the most prevalent pituitary neuroendocrine tumor and dopamine agonists (DAs) targeting dopamine D2 receptor (DRD2) are recommended as the first-line treatment. However, varying degrees of DA resistance limit patient benefit.
Yuyang Peng, Huachun Yin, Xiangdong Pei, Yuan Zhang, Chengcheng Wang, Xin Zheng, Hong Liang, Hui Yang, Song Li   +8 more
doaj   +2 more sources

Descriptive Epidemiology and Survival Analysis of Prolactinomas and Cushing’s Disease in Korea [PDF]

Endocrinology and Metabolism, 2021
Background Only a few studies have established the epidemiology of prolactinoma and Cushing’s disease in Korea. Furthermore, the incidence of these disease are increasing than before associated with the development of technologies.
Jin Sun Park, Soo Jin Yun, Jung Kuk Lee, So Young Park, Sang Ouk Chin   +4 more
doaj   +1 more source

Approach to the Patient With Prolactinoma

Journal of Clinical Endocrinology and Metabolism, 2023
Prolactinomas are the most common pituitary tumor histotype, with microprolactinomas being prevalent in women and macroprolactinomas in men. Hyperprolactinemia is among the most common causes of hypogonadotropic hypogonadism in both sexes, prompting ...
R. Auriemma, R. Pirchio, C. Pivonello, F. Garifalos, A. Colao, R. Pivonello   +5 more
semanticscholar   +1 more source

Surgery as first-line treatment for prolactinoma? Discussion of the literature and results of a consecutive series of surgically treated patients

Neurosurgical review, 2023
Initial treatment for prolactinoma is usually conservative with dopamine agonists. However, the duration of treatment is often lifelong and can be associated with significant side effects.
M. Ottenhausen, J. Conrad, Lea-Marie Wolters, F. Ringel   +3 more
semanticscholar   +1 more source

The Role of Aromatase Inhibitors in Male Prolactinoma

Journal of Clinical Medicine, 2023
Background: dopamine agonists are the recommended treatment for male prolactinomas, but some patients may develop dopamine-agonist-resistant hyperprolactinemia, leading to persistent hypogonadism that requires treatment with testosterone.
A. Akirov, Yaron Rudman
semanticscholar   +1 more source

Update in Pathogenesis, Diagnosis, and Therapy of Prolactinoma

Cancers, 2022
Simple Summary This review updates recent advances in the pathogenesis, diagnosis, and therapy of prolactinoma. Prolactinomas, comprising 30–50% of all pituitary neuroendocrine tumors, frequently occur in females aged 20 to 50 and cause hypogonadism and ...
Noriaki Fukuhara, M. Nishiyama, Y. Iwasaki   +2 more
semanticscholar   +1 more source

Dopamine agonist therapy for prolactinomas: do we need to rethink the place of surgery in prolactinoma management?

Endocrine Oncology, 2022
The current treatment paradigm for prolactinomas involves dopamine agonist (DA) therapy as the first-line treatment, with surgical resection reserved for cases where there is DA failure due to resistance or intolerance.
S. D. De Sousa
semanticscholar   +1 more source

The Effect of Prolactinoma on Tear Film Function

Türk Oftalmoloji Dergisi, 2022
Objectives:To compare dry eye parameters in prolactinoma patients and healthy controls and evaluate their correlation with prolactin (PRL) levels and the duration of hyperprolactinemia.Materials and Methods:Consecutive patients with prolactinoma and ...
Cezmi Doğan, Ümit Yaşar Güleser, Oğuzhan Kılıçarslan, Burak Mergen, Özer Açbay, Güzin İskeleli   +5 more
doaj   +1 more source