Results 151 to 160 of about 3,711,169 (334)

Exosomes derived from M0, M1 and M2 macrophages exert distinct influences on the proliferation and differentiation of mesenchymal stem cells

, 2020
Yu Xia, Xiao‐Tao He, Xinyue Xu, Bei‐Min Tian, Ying An, Fa‐Ming Chen   +5 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

NEK2 promotes the migration and proliferation of ESCC via stabilization of YAP1 by phosphorylation at Thr-143 [PDF]

, 2022
Wei Su, Hao Hu, Qiurong Ding, Min Wang, Yan Zhu, Zhaochao Zhang, Zihan Geng, Shengli Lin, Ping‐Hong Zhou   +8 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Inflammasomes and their roles in autoimmune diseases

Rheumatology & Autoimmunity
Autoimmune diseases are immune disorders in which the immune system mistakenly targets and attacks the normal cells, tissues, and organs of the patients. The etiology of autoimmune diseases is complex and multifactorial.
Minghui Pan, Jie Yang, Zhengfan Jiang
doaj   +1 more source

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

, 2015
Mark A. Feitelson, Alla Arzumanyan, Rob J. Kulathinal, Stacy W. Blain, Randall F. Holcombe, Jamal Mahajna, Maria Marino, Maria Luz Martínez‐Chantar, Roman Nawroth, Isidro Sánchez‐García, Dipali Sharma, Neeraj K. Saxena, Neetu Singh, Panagiotis J. Vlachostergios, Shanchun Guo, Kanya Honoki, Hiromasa Fujii, Alexandros G. Georgakilas, Alan Bilsland, Amedeo Amedei, Elena Niccolai, Amr Amin, S. M. Ashraf, Chandra S. Boosani, Gunjan Guha, Maria Rosa Ciriolo, Katia Aquilano, Sophie Chen, Sulma I. Mohammed, Asfar S. Azmi, Dipita Bhakta-Guha, Dorota Halicka, W. Nicol Keith, Somaira Nowsheen   +33 more
openalex   +1 more source

The invasion-associated type III secretion system of Salmonella enterica serovar Typhimurium is necessary for intracellular proliferation and vacuole biogenesis in epithelial cells [PDF]

, 2002
Olivia Steele‐Mortimer, John H. Brumell, Leigh A. Knodler, Stéphane Méresse, A. Sarut Lopez, B. Brett Finlay   +5 more
openalex   +1 more source

RAB27A promotes the proliferation and invasion of colorectal cancer cells [PDF]

, 2022
Qingyan Li, Huixia Zhao, Weiwei Dong, Na Guan, Yanyan Hu, Zhiyan Zeng, He Zhang, Fengyun Zhang, Qiuwen Li, Jingwen Yang, Wenhua Xiao   +10 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source