Results 81 to 90 of about 3,456,235 (361)

Roles of TGFβ and FGF signals during growth and differentiation of mouse lens epithelial cell in vitro. [PDF]

, 2017
Transforming growth factor β (TGFβ) and fibroblast growth factor (FGF) signaling pathways play important roles in the proliferation and differentiation of lens epithelial cells (LECs) during development.
Gong, Xiaohua, Li, Song, Liu, Kelsey, Wang, Dong, Wang, Eddie, Xia, Chun-Hong   +5 more
core   +2 more sources

DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6

Nature Communications, 2017
Centrosome duplication is synchronized with cell cycle events but how this is regulated at a molecular level is unclear. Here, the authors show that the DNA replication licensing factor Cdc6 restrains centrosome duplication via binding and inhibiting Sas-
Xiaowei Xu, Shijiao Huang, Boyan Zhang, Fan Huang, Wangfei Chi, Jingyan Fu, Gang Wang, Si Li, Qing Jiang, Chuanmao Zhang   +9 more
doaj   +1 more source

Genetic markers of the proliferative syndrome in age-related macular degeneration and chronic angle-closure glaucoma

Российский офтальмологический журнал, 2023
Purpose: clinical and genetic research of primary chronic angle-closure glaucoma (PACG) and age-related macular degeneration (AMD) for prospective pathogenetically-oriented targeted treatment of these condition.Materials and methods.
L. M. Balashova, N. A. Bakunina, A. A. Fedorov, Yu. D. Kuznetsova, A. V. Popov, M. E. Viner   +5 more
doaj   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation [PDF]

, 1993
We have constructed a soluble chimeric fusion protein between the mouse CD8 alpha chain and the mouse CD40 T cell ligand. This protein binds to both human and mouse B cells.
Brocker, Thomas, Hubele, S., Lane, P., Lanzavecchia, A., McConnell, F., Padovan, E.   +5 more
core   +1 more source

Silently Proliferating: Cancer

The Eurasian Journal of Medicine, 2023
Cancer is a health problem that has existed for years and frequently affects tissues and organs. Although some standards have been set for its treatment, different treatments and approaches are used for each type of cancer. The treatment process and having to live with cancer drag the individual to a difficult process that affects the individual ...
DİNCER, Aytap, Coban, Gülay, KÖSE, Asena   +2 more
openaire   +4 more sources

Continuous Time Random Walk and Migration Proliferation Dichotomy [PDF]

, 2015
A theory of fractional kinetics of glial cancer cells is presented. A role of the migration-proliferation dichotomy in the fractional cancer cell dynamics in the outer-invasive zone is discussed an explained in the framework of a continuous time random walk.
arxiv   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Bimerons create bimerons: proliferation and aggregation induced by currents and magnetic fields [PDF]

Aggregate 5, e590 (2024)
The aggregation of topological spin textures at nano and micro scales has practical applications in spintronic technologies. Here, the authors report the in-plane current-induced proliferation and aggregation of bimerons in a bulk chiral magnet. It is found that the spin-transfer torques can induce the proliferation and aggregation of bimerons only in ...
arxiv   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source