Results 61 to 70 of about 2,619,152 (303)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The regulation of haemopoietic stem cell and progenitor cell proliferation by humoral factors [PDF]

, 2012
The mechanisms which regulate the growth fraction of the haemopoietic stem cell (CFU-S) and granulocyte macrophage progenitor cell (GM-CFC) have been investigated.
Cork, Michael John
core   +2 more sources

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science
Intestinal epithelial cells (IEC) are crucial for regulating intestinal local immunity to potentiate mucosal barrier function, but the mechanism remains unclear.
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
doaj   +1 more source

World at Risk: The Report of the Commission on the Prevention of WMD Proliferation and Terrorism [PDF]

, 2008
This book outlines the findings of the bipartisan Commission on the Prevention of Weapons of Mass Destruction Proliferation and Terrorism, established to build on the work of the 9/11 Commission. The Commission's report examines the government's current
Commission on the Prevention of Weapons of Mass Destruction Proliferation and Terrorism (U.S.)
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Ehbp1 orchestrates orderly sorting of Wnt/Wingless to the basolateral and apical cell membranes

EMBO Reports
Wingless (Wg)/Wnt signaling plays a critical role in both development and adult tissue homeostasis. In the Drosophila larval wing disc epithelium, the orderly delivery of Wg/Wnt to the apical and basal cell surfaces is essential for wing development ...
Yuan Gao, Jing Feng, Yansong Zhang, Mengyuan Yi, Lebing Zhang, Yan Yan, Alan Jian Zhu, Min Liu   +7 more
doaj   +1 more source

Mitochondrial Oxidative Stress and Antioxidants Balance in Fatty Liver Disease

Hepatology Communications, 2018
Fatty liver disease is one of the most prevalent forms of chronic liver disease that encompasses both alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD).
Carmen García‐Ruiz, José C. Fernández‐Checa   +1 more
doaj   +1 more source

Single-cell RNA-seq analysis unveils a prevalent epithelial/mesenchymal hybrid state during mouse organogenesis

Genome Biology, 2018
Background Organogenesis is crucial for proper organ formation during mammalian embryonic development. However, the similarities and shared features between different organs and the cellular heterogeneity during this process at single-cell resolution ...
Ji Dong, Yuqiong Hu, Xiaoying Fan, Xinglong Wu, Yunuo Mao, Boqiang Hu, Hongshan Guo, Lu Wen, Fuchou Tang   +8 more
doaj   +1 more source

Manufacturing dissent : the discursive formation of nuclear proliferation (2006-2012) [PDF]

, 2015
This paper draws on the conceptualisation of 'discursive formation' to examine the particular configuration of the ‘objects, subjects, concepts and strategies’ (Foucault, 1972) which constitute ‘nuclear proliferation’ between 2006 and 2012.
Homolar, Alexandra, Lena Rethel, Alexandra Homolar, Rethel, Lena, Malcolm N MacDonald, Schnurr, Stephanie, Vessey, Rachelle, MacDonald, Malcolm, Stephanie Schnurr, Rachelle Vessey   +9 more
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source