Results 41 to 50 of about 3,582,903 (301)

Migration and proliferation dichotomy in tumor cell invasion [PDF]

, 2006
We propose a two-component reaction-transport model for the migration-proliferation dichotomy in the spreading of tumor cells. By using a continuous time random walk (CTRW) we formulate a system of the balance equations for the cancer cells of two ...
A. Iomin, Alexander Iomin, E. W. Montroll, J. D. Murray, M. Freidlin, Sergei Fedotov   +5 more
core   +1 more source

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

Mitochondria and the NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis

Cells, 2022
Alcoholic (ASH) and nonalcoholic steatohepatitis (NASH) are advanced stages of fatty liver disease and two of the most prevalent forms of chronic liver disease.
Sandra Torres, Paula Segalés, Carmen García-Ruiz, José C. Fernández-Checa   +3 more
doaj   +1 more source

Nitric oxide from inflammatory origin impairs neural stem cell proliferation by inhibiting epidermal growth factor receptor signaling [PDF]

, 2014
Neuroinflammation is characterized by activation of microglial cells, followed by production of nitric oxide (NO), which may have different outcomes on neurogenesis, favoring or inhibiting this process.
Alvarez-Buylla, Alvaro, Ana I. Santos, Ana S. Lourenço, António F. Ambrósio, Arvidsson, Bal-Price, Batchelor, Beckman, Beltran, Ben-Hur, Benraiss, Bergsland, Boje, Bruno P. Carreira, Buck, Butovsky, Cacci, Caetana M. Carvalho, Calabrese, Calabrese, Cappella, Carreira, Carreira, Chao, Chehrehasa, Covacu, Curtis, Davalos, Dawson, Dawson, Doetsch, Ekdahl, Ekdahl, Eriksson, Estrada, Gage, Galea, Giulian, Green, Guix, Hanafy, Ignarro, Inês M. Araújo, Iosif, Ischiropoulos, Keefer, Kempermann, Kettenmann, Keynes, Lane, Lowenstein, Madhusoodanan, Maria I. Morte, Matarredona, Ming, Misko, Moncada, Monje, Monje, Monteiro, Moreno-Lopez, Murillo-Carretero, Murillo-Carretero, Murphy, Nathan, Nimmerjahn, Ormerod, Packer, Parent, Pryor, Radi, Reynolds, Rock, Salvemini, Saura, Sierra, Szabo, Taupin, Torroglosa, Uc, Vallieres, Walton, Zhang, Zhang, Zhang   +85 more
core   +2 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing

Nature Communications, 2022
Chromosomal structural variations induced by CRISPR/Cas hinder its application in clinics. Here, the authors fuse Cas9 with optimized TREX2 to generate Cas9TX, which can prevent perfect repair and inhibit repeated cleavage.
Jianhang Yin, Rusen Lu, Changchang Xin, Yuhong Wang, Xinyu Ling, Dong Li, Weiwei Zhang, Mengzhu Liu, Wutao Xie, Lingyun Kong, Wen Si, Ping Wei, Bingbing Xiao, Hsiang-Ying Lee, Tao Liu, Jiazhi Hu   +15 more
doaj   +1 more source

Immunoregulatory Role of the Mechanosensitive Ion Channel Piezo1 in Inflammation and Cancer

Molecules, 2022
Piezo1 was originally identified as a mechanically activated, nonselective cation ion channel, with significant permeability to calcium ions, is evolutionally conserved, and is involved in the proliferation and development of various types of cells, in ...
Yuexin Wang, Zhiyuan Zhang, Qiuli Yang, Yejin Cao, Yingjie Dong, Yujing Bi, Guangwei Liu   +6 more
doaj   +1 more source

Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine [PDF]

, 2016
Reactive oxygen species (ROS) participate in numerous cell responses, including proliferation, DNA damage, and cell death. Based on these disparate activities, both promotion and inhibition of ROS have been proposed for cancer therapy.
Blyth, Karen, Ceteci, Fatih, Cheung, Eric, Lee, Pearl, Nixon, Colin, Sansom, Owen, Vousden, Karen   +6 more
core   +1 more source

A novel method for genetic transformation of yeast cells using oligoelectrolyte polymeric nanoscale carriers

BioTechniques, 2013
The genetic transformation of target cells is a key tool in modern biological research, as well as in many gene therapy and biotechnology applications. Here we describe a new method for delivery of DNA into several industrially important species of yeast,
Yevhen Filyak, Nataliya Finiuk, Nataliya Mitina, Oksana Bilyk, Vladimir Titorenko, Olesya Hrydzhuk, Alexander Zaichenko, Rostyslav Stoika   +7 more
doaj   +1 more source

Sphingomyelinases and Liver Diseases

Biomolecules, 2020
Sphingolipids (SLs) are critical components of membrane bilayers that play a crucial role in their physico-chemical properties. Ceramide is the prototype and most studied SL due to its role as a second messenger in the regulation of multiple signaling ...
Naroa Insausti-Urkia, Estel Solsona-Vilarrasa, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa   +3 more
doaj   +1 more source