Results 21 to 30 of about 3,582,903 (301)

TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging

Nature Communications, 2018
Cellular senescence is associated with epigenetic remodeling. Here, the authors report that TGF-β signaling promotes miR-29 mediated loss of H4K20me3 thus accelerating senescence.
Guoliang Lyu, Yiting Guan, Chao Zhang, Le Zong, Lei Sun, Xiaoke Huang, Li Huang, Lijun Zhang, Xiao-Li Tian, Zhongjun Zhou, Wei Tao   +10 more
doaj   +1 more source

Role of Vitamin K-Dependent Factors Protein S and GAS6 and TAM Receptors in SARS-CoV-2 Infection and COVID-19-Associated Immunothrombosis

Cells, 2020
The vitamin K-dependent factors protein S (PROS1) and growth-arrest-specific gene 6 (GAS6) and their tyrosine kinase receptors TYRO3, AXL, and MERTK, the TAM subfamily of receptor tyrosine kinases (RTK), are key regulators of inflammation and vascular ...
Anna Tutusaus, Montserrat Marí, José T. Ortiz-Pérez, Gerry A. F. Nicolaes, Albert Morales, Pablo García de Frutos   +5 more
doaj   +1 more source

Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes [PDF]

, 2017
Identifying mechanisms by which cells of the osteoblastic lineage communicate in vivo is complicated by the mineralised matrix that encases osteocytes, and thus, vital mechanoadaptive processes used to achieve load‐bearing integrity remain unresolved. We
Aarden, Ajubi, Alford, Bancroft, Batra, Bonewald, Brighton, Bruzzone, Burger, Burger, Burger, Chan, Cheng, Cheng, Cheng, Cheng, Cherian, Cherian, Chiba, Civitelli, Dallas, Damien, Damien, Davidson, Dietrich, Donahue, Doty, Endres, Frost, Genetos, Gluhak-Heinrich, Goldberg, Hasegawa, Heino, Iqbal, Irie, Javaheri, Javaheri, Jiang, Jones, Kamioka, Kato, Kleinnulend, Kulkarni, Lanyon, Nijweide, Osborne, Palumbo, Pitsillides, Rawlinson, Rawlinson, Rawlinson, Rawlinson, Rawlinson, Ren, Schirrmacher, Schwab, Shapiro, Siller-Jackson, Skerry, Skerry, Stanford, Su, Sugawara, Tan, Tanaka, Tanaka-Kamioka, Tatsumi, Taylor, Ulmann, Uzer, Van der Plas, Vazquez, Vezeridis, Weinbaum, Westbroek, Yamaguchi, Yang, Yellowley, You, Zaman, Zaman, Zhao, Ziambaras   +83 more
core   +3 more sources

Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer

eLife, 2022
Dendritic cells (DCs) play an important role in anti-tumor immunity by inducing T cell differentiation. Herein, we found that the DC mechanical sensor Piezo1 stimulated by mechanical stiffness or inflammatory signals directs the reciprocal ...
Yuexin Wang, Hui Yang, Anna Jia, Yufei Wang, Qiuli Yang, Yingjie Dong, Yueru Hou, Yejin Cao, Lin Dong, Yujing Bi, Guangwei Liu   +10 more
doaj   +1 more source

Retinopathy of prematurity: indicators of cellular immunity in patients with various stages of the disease

Российский офтальмологический журнал, 2019
Purpose: to study the role of cellular immunity in the development of retinopathy of prematurity (ROP).Material and methods. 87 children were tested, including 60 with III — V stage ROP and posterior aggressive retinopathy that had gestational age from ...
L. M. Balashova, Y. D. Kuznetsova, L. S. Korobova, E. P. Kantarzhi, V. E. Mukhin, E. A. Cherkashina, S. N. Bykovskaya   +6 more
doaj   +1 more source

CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation [PDF]

, 2017
In germinal centres (GC) mature B cells undergo intense proliferation and immunoglobulin gene modification before they differentiate into memory B cells or long-lived plasma cells (PC).
Galjart, Niels, Ligos, Jose M., Marina-Zárate, Ester, Pérez-García, Arantxa, Ramiro, Almudena R., Álvarez-Prado, Ángel F.   +5 more
core   +5 more sources

A Novel Acyl-AcpM-Binding Protein Confers Intrinsic Sensitivity to Fatty Acid Synthase Type II Inhibitors in Mycobacterium smegmatis

Frontiers in Microbiology, 2022
The fatty acid synthase type II (FAS-II) multienzyme system is the main target of drugs to inhibit mycolic acid synthesis in mycobacterium. Meromycolate extension acyl carrier protein (AcpM) serves as the carrier of fatty acyl chain shuttling among the ...
Mengmiao Li, Qian Huang, Weidi Zhang, Yinghua Cao, Zhanxin Wang, Zhenwen Zhao, Xiaotian Zhang, Junjie Zhang   +7 more
doaj   +1 more source

Functional Integration of Ecological Networks through Pathway Proliferation

, 2006
Large-scale structural patterns commonly occur in network models of complex systems including a skewed node degree distribution and small-world topology. These patterns suggest common organizational constraints and similar functional consequences.
Albert, Albert, Albert, Allen, Allesina, Baird, Bang-Jensen, Barabási, Barabási, Barbosa, Berman, Bernard C. Patten, Borrett, Borrett, Brian D. Fath, Burns, Caldarelli, Caswell, Chase, Christian, Cohen, Cohen, Cvetkoviâc, Cvetkoviâc, de Aguiar, DeAngelis, DeAngelis, Dunne, Dunne, Dunne, Erdös, Erdös, Farkas, Fath, Fath, Fath, Finn, Gardner, Godsil, Goh, Goldwasser, Hall, Havens, Higashi, Higashi, Higashi, Huxham, Jain, Jeong, Jones, Jørgensen, Karp, Kenny, Krause, Laland, Lawler, Link, Luczak, Margalef, Martinez, Martinez, May, May, Maynard Smith, Memmott, Montoya, Moreno, Müller, Neutel, Newman, Newman, Newman, Newman, Odling-Smee, Patten, Patten, Patten, Patten, Patten, Patten, Patten, Patten, Pimm, Pimm, Pimm, Pimm, Pimm, Polis, Polis, Ponstein, Post, Post, Price, Root, Seneta, Simon, Stuart R. Borrett, Townsend, Ulanowicz, Ulanowicz, Ulanowicz, Waide, Warren, Watts, Watts, Whipple, Williams, Williams, Yodzis, Yodzis   +109 more
core   +1 more source

Inhibition of Tendon Cell Proliferation and Matrix Glycosaminoglycan Synthesis by Non-Steroidal Anti-Inflammatory Drugs in vitro [PDF]

, 2002
The purpose of this study was to investigate the effects of some commonly used non-steroidal anti-inflammatory drugs (NSAIDs) on human tendon. Explants of human digital flexor and patella tendons were cultured in medium containing pharmacological ...
B. L HAZLEMAN, Brandt KD, Day RO, Dingle JT, Dingle JT, Flint M, G. P. RILEY, Gelberman RH, Hugenberg ST, M. COX, Martel-Pelletier J, Pelletier J-P, R. L. HARRALL, Rolf C, S. CLEMENTS, Scott JE, Thomas J   +16 more
core   +1 more source

A comparative study of of T regulatory cells numbers (CD4⁺CD25^highFoxP3⁺CD127^low) in patients under 1 year of age with cataract, glaucoma, and retinopathy of prematurity (review of the own studies)

Медицинская иммунология
Potential involvement of immune system in pathophysiology of congenital glaucoma, cataract, and retinopathy of prematurity (ROP) in infants has been suggested. However, its understanding still remains limited.
L. M. Balashova, Yu. D. Kuznetsova, S. V. Lesovoy, M. A. Alvarez, A. A. Balashov, D. R. Cherkashin, E. P. Kantarzhi, S. N. Bykovskaya, Zh. M. Salmasi   +8 more
doaj   +1 more source