Results 11 to 20 of about 2,619,152 (303)

Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model [PDF]

open access: yes, 2013
Neurogenesis is a life long process, but the rate of cell proliferation and differentiation decreases with age. In Alzheimer's patients, along with age, the presence of Aβ in the brain inhibits this process by reducing stem cell proliferation and cell ...
Vadivel Parthsarathy   +7 more
core   +6 more sources

Sox2 maintains epithelial cell proliferation in the successional dental lamina [PDF]

open access: yes, 2020
Objectives: The successional dental lamina is the distinctive structure on the lingual side of the vertebrate tooth germ. The aim of this study was to investigate the relationship among Sox2, Claudin10 and laminin5 and the role of Sox2 in successional ...
Jung, Seo Yoon   +9 more
core   +2 more sources

A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth

open access: yesNature Communications, 2016
Drosophila RNAi libraries are commonly used to perform large-scale functional genetics screens in vivo. Here the authors find that a subset of lines from the VDRC KK RNAi line cause false-positive enhancement of the Hippo pathway, and provide a strain ...
Joseph H.A. Vissers   +3 more
doaj   +1 more source

The Role of Exogenous Stresses on the Proliferation of Intervertebral Disk Cells

open access: yesGlobal Spine Journal, 2012
Introduction The native microenvironment of intervertebral disk (IVD) cells is characterized by adverse physicochemical conditions. Low cellularity and proliferation rate is a hallmark of the disk, possibly resulting from the absence of vascularization ...
A. Dimozi   +3 more
doaj   +1 more source

Genome and epigenome analysis of monozygotic twins discordant for congenital heart disease

open access: yesBMC Genomics, 2018
Background Congenital heart disease (CHD) is the leading non-infectious cause of death in infants. Monozygotic (MZ) twins share nearly all of their genetic variants before and after birth.
Guoliang Lyu   +11 more
doaj   +1 more source

A Prize for Proliferation [PDF]

open access: yesCell, 2001
As an avid reader of the Economist, I was disappointed by their suggestion that the Nobel committee had “blown” it in giving this year's prize for medicine and physiology to the discoverers of Cdks and not to those who had just sequenced the human genome.
openaire   +2 more sources

TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging

open access: yesNature Communications, 2018
Cellular senescence is associated with epigenetic remodeling. Here, the authors report that TGF-β signaling promotes miR-29 mediated loss of H4K20me3 thus accelerating senescence.
Guoliang Lyu   +10 more
doaj   +1 more source

THE ORACLES OF PROLIFERATION [PDF]

open access: yesThe Nonproliferation Review, 2011
By examining via a case study the political authority of US proliferation experts since the 1960s, this article contributes to nuclear weapons proliferation studies and to the growing literature on the role of expertise in democracies. First, it argues that policy choices are determined by an understanding of history and that approaching nuclear ...
openaire   +3 more sources

Role of Vitamin K-Dependent Factors Protein S and GAS6 and TAM Receptors in SARS-CoV-2 Infection and COVID-19-Associated Immunothrombosis

open access: yesCells, 2020
The vitamin K-dependent factors protein S (PROS1) and growth-arrest-specific gene 6 (GAS6) and their tyrosine kinase receptors TYRO3, AXL, and MERTK, the TAM subfamily of receptor tyrosine kinases (RTK), are key regulators of inflammation and vascular ...
Anna Tutusaus   +5 more
doaj   +1 more source

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