Results 11 to 20 of about 1,878,563 (219)

Genome and epigenome analysis of monozygotic twins discordant for congenital heart disease

BMC Genomics, 2018
Background Congenital heart disease (CHD) is the leading non-infectious cause of death in infants. Monozygotic (MZ) twins share nearly all of their genetic variants before and after birth.
Guoliang Lyu, Chao Zhang, Te Ling, Rui Liu, Le Zong, Yiting Guan, Xiaoke Huang, Lei Sun, Lijun Zhang, Cheng Li, Yu Nie, Wei Tao   +11 more
doaj   +1 more source

TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging

Nature Communications, 2018
Cellular senescence is associated with epigenetic remodeling. Here, the authors report that TGF-β signaling promotes miR-29 mediated loss of H4K20me3 thus accelerating senescence.
Guoliang Lyu, Yiting Guan, Chao Zhang, Le Zong, Lei Sun, Xiaoke Huang, Li Huang, Lijun Zhang, Xiao-Li Tian, Zhongjun Zhou, Wei Tao   +10 more
doaj   +1 more source

Role of Vitamin K-Dependent Factors Protein S and GAS6 and TAM Receptors in SARS-CoV-2 Infection and COVID-19-Associated Immunothrombosis

Cells, 2020
The vitamin K-dependent factors protein S (PROS1) and growth-arrest-specific gene 6 (GAS6) and their tyrosine kinase receptors TYRO3, AXL, and MERTK, the TAM subfamily of receptor tyrosine kinases (RTK), are key regulators of inflammation and vascular ...
Anna Tutusaus, Montserrat Marí, José T. Ortiz-Pérez, Gerry A. F. Nicolaes, Albert Morales, Pablo García de Frutos   +5 more
doaj   +1 more source

Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer

eLife, 2022
Dendritic cells (DCs) play an important role in anti-tumor immunity by inducing T cell differentiation. Herein, we found that the DC mechanical sensor Piezo1 stimulated by mechanical stiffness or inflammatory signals directs the reciprocal ...
Yuexin Wang, Hui Yang, Anna Jia, Yufei Wang, Qiuli Yang, Yingjie Dong, Yueru Hou, Yejin Cao, Lin Dong, Yujing Bi, Guangwei Liu   +10 more
doaj   +1 more source

Retinopathy of prematurity: indicators of cellular immunity in patients with various stages of the disease

Российский офтальмологический журнал, 2019
Purpose: to study the role of cellular immunity in the development of retinopathy of prematurity (ROP).Material and methods. 87 children were tested, including 60 with III — V stage ROP and posterior aggressive retinopathy that had gestational age from ...
L. M. Balashova, Y. D. Kuznetsova, L. S. Korobova, E. P. Kantarzhi, V. E. Mukhin, E. A. Cherkashina, S. N. Bykovskaya   +6 more
doaj   +1 more source

A comparative study of of T regulatory cells numbers (CD4⁺CD25^highFoxP3⁺CD127^low) in patients under 1 year of age with cataract, glaucoma, and retinopathy of prematurity (review of the own studies)

Медицинская иммунология
Potential involvement of immune system in pathophysiology of congenital glaucoma, cataract, and retinopathy of prematurity (ROP) in infants has been suggested. However, its understanding still remains limited.
L. M. Balashova, Yu. D. Kuznetsova, S. V. Lesovoy, M. A. Alvarez, A. A. Balashov, D. R. Cherkashin, E. P. Kantarzhi, S. N. Bykovskaya, Zh. M. Salmasi   +8 more
doaj   +1 more source

Temporospatial induction of homeodomain gene cut dictates natural lineage reprogramming

eLife, 2018
Understanding how cellular identity naturally interconverts with high efficiency and temporospatial precision is crucial for regenerative medicine. Here, we revealed a natural midgut-to-renal lineage conversion event during Drosophila metamorphosis and ...
Ke Xu, Xiaodan Liu, Yuchun Wang, Chouin Wong, Yan Song   +4 more
doaj   +1 more source

A Novel Acyl-AcpM-Binding Protein Confers Intrinsic Sensitivity to Fatty Acid Synthase Type II Inhibitors in Mycobacterium smegmatis

Frontiers in Microbiology, 2022
The fatty acid synthase type II (FAS-II) multienzyme system is the main target of drugs to inhibit mycolic acid synthesis in mycobacterium. Meromycolate extension acyl carrier protein (AcpM) serves as the carrier of fatty acyl chain shuttling among the ...
Mengmiao Li, Qian Huang, Weidi Zhang, Yinghua Cao, Zhanxin Wang, Zhenwen Zhao, Xiaotian Zhang, Junjie Zhang   +7 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Meru co-ordinates spindle orientation with cell polarity and cell cycle progression

The EMBO Journal
Correct mitotic spindle alignment is essential for tissue architecture and plays an important role in cell fate specification through asymmetric cell division.
Melissa M McLellan, Birgit L Aerne, Jennifer J Banerjee Dhoul, Maxine V Holder, Tania Auchynnikava, Nicolas Tapon   +5 more
doaj   +1 more source