Results 91 to 100 of about 768,209 (306)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Aging and Immortality in a Cell Proliferation Model

, 2008
We investigate a model of cell division in which the length of telomeres within the cell regulate their proliferative potential. At each cell division the ends of linear chromosomes change and a cell becomes senescent when one or more of its telomeres ...
Abramowitz, Bailey, Bailey, Bryan, Campisi, Campisi, Campisi, Carey, Fleming, Gikhman, Gradshteyn, Harley, Hasenmaile, Hayflick, Henson, K.B. Blagoev, Karlin, Nisbet, Olovnikov, Reddel, Redner, S. Redner, S.A. Trugman, Steinsaltz, T. Antal, Watson, Weitz   +26 more
core   +1 more source

Early suppression of lymphoproliferative response in dogs with natural infection by Leishmania infantum. [PDF]

, 1999
Dogs are the domestic reservoirs of zoonotic visceral leishmaniasis caused by Leishmania infantum. Early detection of canine infections evolving to clinically patent disease may be important to leishmaniasis control.
CIARAMELLA, PAOLO, DE LUNA R., GRADONI L., IELPO M. T. L. AMBROSIO R., MANCINO D., MOSCATIELLO V., PIANTEDOSI, DIEGO, SCALONE A., VUOTTO M. L.   +8 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Relation between 25-hydroxy vitamin D and diabetic retinopathy in Egyptian patients with type 2 diabetes mellitus

Journal of the Arab Society for Medical Research
Background/aim Diabetic retinopathy (DR) is one of the leading causes of blindness in people whose ages range from 20 to 64 worldwide. This study aims to evaluate the association of serum 25-hydroxy (OH) vitamin D deficiency and DR in type 2 diabetes ...
Mervat E. Elwakeel, Fatma M. El-Senosy, Nesma S. Mohammed, Heba M. Abdelrahman, Eman E. Ebrihem   +4 more
doaj   +1 more source

Adenovirus vector-specific T cells demonstrate a unique memory phenotype with high proliferative potential and coexpression of CCR5 and integrin α\(_4\)β\(_7\) [PDF]

, 2009
Background: The Step Study was a randomized trial to reduce HIV infection through vaccination with an adenovirus type 5-based gag/pol/nef construct; analysis following early cessation of the trial revealed an excess of HIV seroconversion in Ad5 ...
Chakupurakal, Geothy, Cobbold, Mark, Mautner, Vivien, Moss, Paul AH, Onion, David   +4 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Assembly of Protein 4.1 during Chicken Erythroid Differentiation [PDF]

, 1986
Protein 4.1 is a peripheral membrane protein that strengthens the actin-spectrin based membrane skeleton of the red blood cell and also serves to attach this structure to the plasma membrane. In avian erythrocytes it exists as a family of closely related
Lazarides, Elias, Staufenbiel, Matthias
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Major Loss of the 28-kD Protein of Gap Junction in Proliferating Hepatocytes [PDF]

, 1987
There is a reduction in the 28-kD gap junction protein detectable by immunofluorescence in livers of partially hepatectomized rats and in cultured hepatocytes stimulated to proliferate. By the coordinate use of antibodies directed to the hepatic junction
Dermietzel, Rolf, Revel, Jean-Paul, Traub, Otto, Willecke, Kaus, Yancey, S. Barbara   +4 more
core   +1 more source