Results 91 to 100 of about 597,091 (260)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Proliferative and survival pathways in oesophageal cancer [PDF]

, 2011
Includes abstract.Includes bibliographical references.Oesophageal squamous cell carcinoma (OSCC) is the 8th most common cancer worldwide with high incidence in areas that include China, Iran and South Africa. The current treatment available for OSCC does
Esau, Luke Emmanuel
core   +1 more source

Derlin mutants have smaller proliferative zone sizes.

, 2021
A. Representative images of distal germlines of wildtype(WT), cup-2(tm2838); der-2(tm6098), glp-1(ar202) and cup-2(tm2838); der-2(tm6098) glp-1(ar202) worms stained by DAPI to visualize nuclei. Asterisk, distal tip. Dashed line, transition zone.
Ramya Singh (11473498), Hilary Racher (11473504), Ryan B. Smit (11473501), Xin Wang (91924), Dave Hansen (5411927), Chris Wang (9188870)   +5 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Proliferative Effects of Chishao on Schwann Cells are FGF-uPA, and ERK- and JNK-Dependent

, 2012
[[abstract]]"This study evaluated the proliferative effects of chishao on RSC96, Schwann cells. A dose-dependent proliferative effect of chishao was obtained by methylthiazol tetrazolium (MTT), proliferating cell nuclear antigen (PCNA) Western blotting ...
Huang, Kun Shan;Lu, Min-Jin;Chen, Yueh-Sheng;Tsai, Fuu-Jen;Kuo, Wei-Wen;Cheng, Yi-Chang;Lin, Chien-Chung;Tsai, Chang-Hai;黃志揚;HUANG, CHIH-YANG;Lin, Jaung-Geng;Ou, Hsiu-Chung
core  

The non-proliferative nature of ascidian folliculogenesis as a model of highly ordered cellular topology distinct from proliferative epithelia. [PDF]

, 2015
Previous studies have addressed why and how mono-stratified epithelia adopt a polygonal topology. One major additional, and yet unanswered question is how the frequency of different cell shapes is achieved and whether the same distribution applies ...
Rousset, Francois, Yoann Chelin, Stephen Baghdiguian (370813), Mangeat, Paul, Paul Mangeat (375016), Karim Azzag (743628), Le Goff, Emilie, Emilie Le Goff, Camille Martinand-Mari (375008), Anne-Marie Martinez, Maurin, Bernard, Stephen Baghdiguian, Paul Mangeat, Julien Averseng, Julien Averseng (743633), Averseng, Julien, Emilie Le Goff (743630), François Rousset, Baghdiguian, Stephen, Martine Daujat-Chavanieu (407327), Martinez, Anne-Marie, François Rousset (241745), Bernard Maurin (743632), Nelly Godefroy (483441), Godefroy, Nelly, Martinand-Mari, Camille, Chélin, Yoann, Daujat-Chavanieu, Martine, Yoann Chelin (743629), Anne-Marie Martinez (743631), Nelly Godefroy, Camille Martinand-Mari, Azzag, Karim, Karim Azzag, Bernard Maurin, Martine Daujat-Chavanieu   +35 more
core   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Prognostic Factors for Patients with Proliferative Hepatocellular Carcinoma After Liver Resection

Journal of Hepatocellular Carcinoma, 2023
Hong-Mei Li,* Wei Huang,* Chao Hu, Zi-Shu Zhang, Yu-Dong Xiao, Tian-Cheng Wang Department of Radiology, the Second Xiangya Hospital of Central South University, Changsha, People’s Republic of China*These authors contributed equally to this ...
Li HM, Huang W, Hu C, Zhang ZS, Xiao YD, Wang TC   +5 more
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source