Results 51 to 60 of about 7,191 (206)

From Neurotransmission to Retinal Pathophysiology: Unraveling the Role of GABA Receptors in Retinal Disease Progression

open access: yesJournal of Neurochemistry, Volume 169, Issue 8, August 2025.
GABA receptors, widely expressed in the retina, play a key role in lateral inhibition and synaptic regulation. Emerging evidence links their dysregulation to retinal diseases such as diabetic retinopathy, retinitis pigmentosa, glaucoma, and age‐related macular degeneration.
Alan E. Medina Arellano   +5 more
wiley   +1 more source

CHARACTERISTICS OF RETINAL DETACHMENT PATIENTS WITH PROLIFERATIVE VITREORETINOPATHY AT Dr. SOETOMO GENERAL ACADEMIC HOSPITAL

open access: yesIJRETINA (International Journal of Retina), 2019
Introduction: The aim of this study is to evaluate the incidence and characteristics of retinal detachment patients with proliferative vitreoretinopathy.
Ifan Romadhon Lukmana   +7 more
doaj   +1 more source

A Retrospective Clinical Study of the Etiology and Post-operative Visual Outcome of Rhegmatogenous Retinal Detachment [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2014
Aim: To study the etiology of rhegmatogenous retinal detachment and visual outcome after retinal detachment surgery. Materials and methods: Retrospective study conducted at the tertiary eye care hospital over a period of one year.
Achyut N Pandey, Anil Kakde
doaj   +1 more source

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 14, Page 3109-3134, July 2025.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf   +10 more
wiley   +1 more source

Salinomycin inhibits proliferative vitreoretinopathy formation in a mouse model.

open access: yesPLoS ONE, 2020
Proliferative vitreoretinopathy (PVR) is a progressive disease that develops in a subset of patients who undergo surgery for retinal detachment repair, and results in significant vision loss.
Alison M Heffer   +5 more
doaj   +1 more source

Internal closure of a posterior perforation using amniotic membrane: A novel surgical technique

open access: yes
Acta Ophthalmologica, EarlyView.
J. S. Suwandi   +7 more
wiley   +1 more source

Phenotypic Expansion of Knobloch Syndrome Type 2 in an Individual With a De Novo PAK2 Variant

open access: yesAmerican Journal of Medical Genetics Part A, Volume 197, Issue 6, June 2025.
ABSTRACT P21‐activated kinase 2 (PAK2) is a serine/threonine kinase essential for a variety of cellular processes including signal transduction, cellular survival, proliferation, and migration. A recent report proposed monoallelic PAK2 variants cause Knobloch syndrome type 2 (KNO2)—a developmental disorder primarily characterized by ocular anomalies ...
Elizabeth A. Werren   +10 more
wiley   +1 more source

The effect of axial length on pseudophakic retinal detachment

open access: yesActa Ophthalmologica, Volume 103, Issue 2, Page 146-151, March 2025.
Abstract Purpose The purpose of the study was to analyse the surgical management and outcome regarding axial length in the population affected by pseudophakic retinal detachment (PRD) 2015–2020. Method The patients included were from an observational cohort study of patients undergoing cataract surgery in the region of Skåne during 2015–2017. Data were
Joakim Thylefors   +2 more
wiley   +1 more source

Hybrid wide-angle viewing-endoscopic vitrectomy using a 3D visualization system

open access: yesClinical Ophthalmology, 2018
Mihori Kita, Yuki Mori, Sachiyo Hama Department of Ophthalmology, National Organization Kyoto Medical Center, Kyoto, Japan Purpose: To introduce a hybrid wide-angle viewing-endoscopic vitrectomy, which we have reported, using a 3D visualization system ...
Kita M, Mori Y, Hama S
doaj  

Clinical and genetic characteristics and natural history of Finnish families with familial exudative vitreoretinopathy due to pathogenic FZD4 variants

open access: yesActa Ophthalmologica, Volume 103, Issue 2, Page 152-161, March 2025.
Abstract Purpose To report clinical and genetic characteristics of familial exudative vitreoretinopathy (FEVR) in the Finnish population. Methods Detailed clinical and genetic data of 35 individuals with heterozygous pathogenic variants in FZD4 were gathered and analysed.
Laura Lähteenoja   +6 more
wiley   +1 more source

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