Results 121 to 130 of about 872 (179)
New pharmacological agents and emerging therapeutic targets for painful diabetic neuropathy. [PDF]
Front Endocrinol (Lausanne)Panou T, Papanas N, Kempler P.
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LC-MS/MS method for proline-glycine-proline and acetylated proline-glycine-proline in human plasma
Journal of Chromatography B, 2023The extracellular cellular matrix (ECM) maintains tissue structure and regulates signaling functions by continuous degradation and remodeling. Inflammation or other disease conditions activate proteases including matrix metalloproteinases (MMPs) that degrade ECM proteins and in particular generate fragments of collagen and elastin, some of which are ...
Ekta Tiwary +5 more
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Control of Proline Biosynthesis by Proline and Proline Analogues
Nature, 1966MICRO-ORGANISMS prevent over-production of amino -acids by two mechanisms: (a) end-product inhibition of the action of the first specific enzyme in the biosynthetic sequence, and (b) inhibition of the synthesis of all the enzymes in the sequence (enzyme repression)1,2. A number of growth-inhibitory analogues of normal protein amino-acids, besides being
H, Tristram, C F, Thurston
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Proline and proline derivatives as anticonvulsants
General Pharmacology: The Vascular System, 19891. The anticonvulsant properties of L-proline, of proline derivatives (trans-4-hydroxy-L-proline, cis-4-hydroxy-D-proline, 3,4-dehydro-D,L-proline) and of D- and L-pipecolic acid were studied alone and in combination with vigabatrin (R/S-4-aminohex-5-enoic acid).
S, Sarhan, N, Seiler
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EcoSal Plus, 2007
Proline was among the last biosynthetic precursors to have its biosynthetic pathway unraveled. This review recapitulates the findings on the biosynthesis and transport of proline. Glutamyl kinase (GK) catalyzes the ATP-dependent phosphorylation of L-glutamic acid.
Laszlo N, Csonka, Thomas, Leisinger
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Proline was among the last biosynthetic precursors to have its biosynthetic pathway unraveled. This review recapitulates the findings on the biosynthesis and transport of proline. Glutamyl kinase (GK) catalyzes the ATP-dependent phosphorylation of L-glutamic acid.
Laszlo N, Csonka, Thomas, Leisinger
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Journal of the American Chemical Society, 1977
The present study concerns the energies of the conformations of proline. We present results of an improved molecular mechanics calculation for ring conformations of Ac-Pro-OCH/sub 3/ and for the s-cis and s-trans conformations. Internal coordinates including all torsions have been calculated from crystal coordinates for more than 40 x-ray ...
D F, De Tar, N P, Luthra
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The present study concerns the energies of the conformations of proline. We present results of an improved molecular mechanics calculation for ring conformations of Ac-Pro-OCH/sub 3/ and for the s-cis and s-trans conformations. Internal coordinates including all torsions have been calculated from crystal coordinates for more than 40 x-ray ...
D F, De Tar, N P, Luthra
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Applied Biochemistry and Biotechnology, 2022
D-proline and N-boc-5-hydroxy-L-proline are key chiral intermediates in the production of eletriptan and saxagliptin, respectively. An efficient proline racemase-proline dehydrogenase cascade was developed for the enantioselective production of D-proline.
Fanfan Zhang +4 more
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D-proline and N-boc-5-hydroxy-L-proline are key chiral intermediates in the production of eletriptan and saxagliptin, respectively. An efficient proline racemase-proline dehydrogenase cascade was developed for the enantioselective production of D-proline.
Fanfan Zhang +4 more
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Supported proline and proline-derivatives as recyclable organocatalysts
Chemical Society Reviews, 2008In the last eight years, L-proline and L-proline derivatives, such as substituted prolinamides or pyrrolidines, have been successfully used as organocatalysts in several reactions. In this critical review we summarize the immobilization procedures of such organocatalysts highlighting their application, recoverability and reusability (86 references).
GRUTTADAURIA, Michelangelo +2 more
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Proline metabolism in cartilage: The importance of proline biosynthesis
Metabolism, 1978Abstract Mammalian cells have the capacity to synthesize proline from ornithine or glutamic acid, although preformed proline usually is available from extracellular sources. We have measured the rate of proline formation from ornithine in the presence of physiologic concentrations of proline. In rat xiphoid cartilage organ cultures with ornithine and
R J, Smith, J M, Phang
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