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Chemical Reviews
Within the canonical repertoire of the amino acid involved in protein biogenesis, proline plays a unique role as an amino acid presenting a modified backbone rather than a side-chain. Chemical structures that mimic proline but introduce changes into its specific molecular features are defined as proline analogues.
Vladimir Kubyshkin, Marina Rubini
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Within the canonical repertoire of the amino acid involved in protein biogenesis, proline plays a unique role as an amino acid presenting a modified backbone rather than a side-chain. Chemical structures that mimic proline but introduce changes into its specific molecular features are defined as proline analogues.
Vladimir Kubyshkin, Marina Rubini
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Proline incorporation into the proline and hydroxyproline of earthworm-cuticle collagen
Biochimica et Biophysica Acta (BBA) - General Subjects, 1965Abstract Studies in vivo of the incorporation of proline into earthworm cuticle have shown that, as with vertebrate collagens, proline and not free hydroxyproline is the source of both proline and hydroxyproline in cuticle collagen. Purified salt-soluble cuticle collagen preparations contain a component highly labeled in proline and resistant to ...
D, Fujimoto, E, Adams
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Mechanism-based inhibition of proline dehydrogenase by proline analogues
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1993The inactivation of proline dehydrogenase by several L-Pro analogues was investigated with the aim to block the essential metabolic pathway of tsetse flies allowing the degradation of L-Pro to L-Glu. In vitro studies on rat liver mitochondria showed that only 4-methylene-L-proline was able to inactivate proline dehydrogenase.
D, Tritsch, H, Mawlawi, J F, Biellmann
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Plasma proline kinetics and the regulation of proline synthesis in man
Metabolism, 1987A quantitative exploration of the regulation of plasma proline concentration, proline oxidation, and proline endogenous biosynthesis was undertaken utilizing a 360-minute primed continuous infusion of L-[1-13C]proline and L-[methyl-2H3]leucine in healthy, postabsorptive young men.
T, Jaksic +3 more
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Effect of Dietary Proline on Proline Metabolism in the Neonatal Pig
The Journal of Nutrition, 1989The effect of two dietary concentrations of proline (10.3 and 15.8 g/kg) on proline-metabolizing enzymes [pyrroline-5-carboxylate (P5C) reductase and proline oxidase], plasma and tissue free proline concentrations and growth were investigated in the 2- to 13-d-old pig. Diet had no effect on growth or enzyme activity. Diet had a significant (P less than
S E, Samuels, H L, Aarts, R O, Ball
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Fasciolicidal potential of proline analogues and proline biosynthesis inhibitors
International Journal for Parasitology, 1982Abstract Sheers Marion , Campbell Anne J. , Beames D. J. , Edwards S. R. , Moore R. J. and Montague P. E. 1982. Fasciolicidal potential of proline analogues and proline biosynthesis inhibitors. International Journal for Parasitology 12 : 47–52.
M, Sheers +5 more
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Proline and hepatic lipogenesis
Biochimica et Biophysica Acta (BBA) - General Subjects, 1984The effects of proline on lipogenesis in isolated rat hepatocytes were determined and compared with those of lactate, an established lipogenic precursor. Proline or lactate plus pyruvate increased lipogenesis (measured with 3H2O) in hepatocytes from fed rats depleted of glycogen in vitro and in hepatocytes from starved rats.
M C, Sugden +3 more
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Proline and Hydroxyproline in Leaves
Nature, 1952IN the course of investigations on the nitrogen metabolism of plants, the distribution of free amino-acids in the leaves of a number of plant species was studied by the circular paper chromatographic technique1. The occurrence of proline and hydroxy-proline in relatively high concentrations in some of the leaves investigated prompted us to report these
K V, GIRI +3 more
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