Results 121 to 130 of about 658,113 (299)

Effects of prolonged light exposure, GABA, and glycine on horizontal cell responses in tiger salamander retina

, 1989
1. The effects of prolonged light exposure, gamma-aminobutyric acid (GABA), and glycine on the horizontal cell (HC) light responses were studied in the superfused flat-mounted isolated retinas of the larval tiger salamander. 2.
X. L. Yang, S. M. Wu
core   +1 more source

The effectiveness of a remote intensive trauma-focused treatment programme for PTSD

European Journal of Psychotraumatology
Background: Limited research has addressed the efficacy of remote intensive trauma-focused treatment programmes.Objective: This study aims to assess the effectiveness of a remote intensive treatment programme in reducing symptoms of Post-Traumatic Stress
Nienke Ellenbroek, Mae D. Nuijs, Suzy J. M. A. Matthijssen   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Impact of prolonged digital screens exposure on ocular surface and management

, 2021
Background:Prolonged digital screen exposure is the cause of several symptomatic eye issues.Aim:To evaluate the effect of prolonged screen time on ocular surface.Material and methods:This was a prospective, observational and longitudinal study was ...
Mishra, Gireesh
core  

Evidence for epigenetic alterations in PTSD

European Journal of Psychotraumatology, 2012
Rationale/statement of the problem : Neuropeptide Y (NPY) is a peptide with behaviorally relevant effects on the hippocampus and is thought to function as an endogenous anxiolytic.
Janine D. Flory, Linda M. Bierer, Frank Desarnaud, Iouri Makotkine, Ashik Siddique, Charles Marmar, Rachel Yehuda   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Acute biomechanical responses to a prolonged standing exposure in a simulated occupational setting

, 2010
Prolonged occupational standing has previously been associated with low back pain (LBP) development. The immediate effects of a bout of prolonged standing on subsequent functional movement performance have not been investigated.
Howarth, Samuel J., Callaghan, Jack P., Nelson-Wong, Erika   +2 more
core  

The Effects of Prolonged Water Exposure on Human Skin

Journal of Investigative Dermatology, 1973
To gain insight into the pathogenesis of warm-water immersion dermatoses, an experimental technique was developed whereby skin sites on human subjects could be continuously exposed to water for varying time periods simulating actual exposures received by affected patients.
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source