Results 121 to 130 of about 146,778 (328)

ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke

Advanced Science, EarlyView.
Anesthesia‐induced preconditioning protects against perioperative stroke. By manipulating ATF5 in excitatory neurons, it is shown that anesthesia‐driven ATF5 upregulation activates the mitochondrial unfolded protein response (UPRmt) and elevates GDF15 expression.
Xianshu Ju, Tao Zhang, Jianchen Cui, Yulim Lee, Suho Lee, Ho Min Kim, Boohwi Hong, Jiho Park, Chul Hee Choi, Hyon‐Seung Yi, Jun Young Heo, Woosuk Chung   +11 more
wiley   +1 more source

Mechanical Ventilation Weaning in Inclusion Body Myositis: Feasibility of Isokinetic Inspiratory Muscle Training as an Adjunct Therapy

Case Reports in Critical Care, 2014
Inclusion body myositis is a rare myopathy associated with a high rate of respiratory complications. This condition usually requires prolonged mechanical ventilation and prolonged intensive care stay.
Leonardo Cordeiro de Souza, Josué Felipe Campos, Leandro Possidente Daher, Priscila Furtado da Silva, Alex Ventura, Pollyana Zamborlini do Prado, Daniele Brasil, Debora Mendonça, Jocemir Ronaldo Lugon   +8 more
doaj   +1 more source

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

ONE-YEAR OUTCOMES IN PROLONGED MECHANICAL VENTILATION PATIENTS AFTER SIX-WEEK PHYSICAL TRAINING [PDF]

, 2007
Liying Wang, Chien-Ling Su, Ling-Ling Chiang, Ying‐Tai Wu, Huey‐Dong Wu   +4 more
openalex   +1 more source

Design and operation of the air-cooled beam dump for the extraction line of CERN's Proton Synchrotron Booster (PSB)

, 2019
A new beam dump has been designed, built, installed and operated to withstand the future proton beam extracted from the Proton Synchrotron Booster (PSB) in the framework of the LHC Injector Upgrade (LIU) Project at CERN, consisting of up to 1E14 protons ...
Calviani, Marco, Ciccotelli, Alessia, Kaiser, Paul, Perillo-Marcone, Antonio, Sarrio, Alba, Solieri, Nicola, Venturi, Valentina, Vlachoudis, Vasilis   +7 more
core   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Extracorporeal membrane oxygenation improves survival in a novel 24-hour pig model of severe acute respiratory distress syndrome [PDF]

, 2016
Indexación: Web of Science; Pub Med CentralExtracorporeal membrane oxygenation (ECMO) is increasingly being used to treat severe acute respiratory distress syndrome (ARDS).
Alegría, Leyla, Amthauer, Macarena, Araos, Joaquín, Bruhn, Alejandro, Bugedo, Guillermo, Carreño, Pamela, Castro, Gabriel, Cruces, Pablo, Damiani, Felipe, Erranz, Benjamín, García, Patricio, Medina, Tania, Retamal, Jaime, Rodriguez, Felipe, Salomon, Tatiana, Soto, Dagoberto, Tapia, Pablo   +16 more
core  

Replacing BPA: Structural Substitutes BPAF Binding to the Progesterone Receptor Elevates Breast Cancer Risk

Advanced Science, EarlyView.
This study demonstrates that bisphenol analogues, particularly BPAF, bind to progesterone receptor, promoting breast cancer cell proliferation, migration, and mammary tumor growth, indicating that bisphenol A substitutes may pose equal or greater health risks.
Xiaotong Ji, Peilin Li, Haoyang Wu, Linzhuo Shen, Xiaoyun Wu, Peiyun Jiang, Yating Li, Xiaozheng Zhang, Huifeng Yue   +8 more
wiley   +1 more source

Admission Hyperglycemia in Acute Type A Aortic Dissection Predicts for a Prolonged Duration of Mechanical Ventilation

, 2022
Lingyu Lin, Yanjuan Lin, Yanchun Peng, Xizhen Huang, Xuecui Zhang, Liangwan Chen, Sailan Li   +6 more
openalex   +2 more sources

Evaluating a trainee’s progress in surgical dexterity [PDF]

, 2005
The local cardiac surgical training program is modelled on a one-to-one apprenticeship encompassing a number of years. Trainee progress is regularly audited and work of increasing complexity is provided, commensurate with the trainee's ability. Speed and
Manche, Alexander, Schembri, Kevin
core