Results 31 to 40 of about 84,226 (258)

The Long-Term Survival of Intracranial Hemorrhage Patients Successfully Weaned from Prolonged Mechanical Ventilation

International Journal of General Medicine, 2021
Chienhsiu Huang,1 Jin-cherng Chen2,3 1Department of Internal Medicine, Division of Chest Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan; 2Department of Surgery, Division of Neurosurgery, Dalin Tzu Chi Hospital ...
Huang C, Chen J
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The Age of Older Patients Requiring Prolonged Mechanical Ventilation Is Not the Sole Determinant of Their Long-Term Survival

Medicina
Background and Objectives: There are few data on the effects of prolonged mechanical ventilation on elderly patients. Our objective is to investigate the effects of prolonged mechanical ventilation on older patients’ successful weaning and long-term ...
Chienhsiu Huang
doaj   +1 more source

Prolonged propofol infusion for mechanically ventilated children [PDF]

Anaesthesia, 2016
Summary We retrospectively analysed 30‐day mortality and duration of intubation for 8016 children ventilated for three or more days, sedated with midazolam (n = 7716) or propofol (n = 300). We matched the propensity scores of 263 pairs of children.
Y, Sasabuchi, H, Yasunaga, H, Matsui, A K, Lefor, K, Fushimi   +4 more
openaire   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Mechanical ventilation induces brainstem inflammation in preterm fetal sheep

Frontiers in Pediatrics, 2023
BackgroundPreterm infants have immature respiratory drive and often require prolonged periods of mechanical ventilation. Prolonged mechanical ventilation induces systemic inflammation resulting in ventilation-induced brain injury, however its effect on ...
Kayla Vidinopoulos, Kayla Vidinopoulos, Zahrah Azman, Zahrah Azman, Ainsley Somers, Ainsley Somers, Valerie A. Zahra, Alison Thiel, Hui Lu, Yen Pham, Nhi Thao Tran, Nhi Thao Tran, Beth J. Allison, Beth J. Allison, Eric Herlenius, Stuart Hooper, Stuart Hooper, Robert Galinsky, Robert Galinsky, Graeme R. Polglase, Graeme R. Polglase   +20 more
doaj   +1 more source

Prolonged mechanical ventilation as a consequence of acute illness [PDF]

Archives of Disease in Childhood, 1998
To determine why acutely ill children become dependent upon mechanical ventilation and what happens to them.A retrospective medical record study of all patients aged between 1 month and 16 years from 1983 to 1996 who required ventilation for more than 28 days.Forty children were ventilated for between 36 and 180 days before discharge or death.
J, Fraser, T, Henrichsen, Q, Mok, R C, Tasker   +3 more
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Association between procalcitonin levels and duration of mechanical ventilation in COVID-19 patients

PLoS ONE, 2020
Background Patients diagnosed with COVID-19 frequently require mechanical ventilation. Knowledge of laboratory tests associated with the prolonged need for mechanical ventilation may guide resource allocation.
Martin Krause, David J. Douin, Timothy T. Tran, Ana Fernandez-Bustamante, Muhammad Aftab, Karsten Bartels, Wenbin Tan   +6 more
doaj   +2 more sources