Results 41 to 50 of about 87,591 (293)

Mechanical ventilation induces brainstem inflammation in preterm fetal sheep

Frontiers in Pediatrics, 2023
BackgroundPreterm infants have immature respiratory drive and often require prolonged periods of mechanical ventilation. Prolonged mechanical ventilation induces systemic inflammation resulting in ventilation-induced brain injury, however its effect on ...
Kayla Vidinopoulos, Kayla Vidinopoulos, Zahrah Azman, Zahrah Azman, Ainsley Somers, Ainsley Somers, Valerie A. Zahra, Alison Thiel, Hui Lu, Yen Pham, Nhi Thao Tran, Nhi Thao Tran, Beth J. Allison, Beth J. Allison, Eric Herlenius, Stuart Hooper, Stuart Hooper, Robert Galinsky, Robert Galinsky, Graeme R. Polglase, Graeme R. Polglase   +20 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Long-Term Survival of Intracranial Hemorrhage Patients Successfully Weaned from Prolonged Mechanical Ventilation

International Journal of General Medicine, 2021
Chienhsiu Huang,1 Jin-cherng Chen2,3 1Department of Internal Medicine, Division of Chest Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan; 2Department of Surgery, Division of Neurosurgery, Dalin Tzu Chi Hospital ...
Huang C, Chen J
doaj  

Prolonged propofol infusion for mechanically ventilated children [PDF]

Anaesthesia, 2016
Summary We retrospectively analysed 30‐day mortality and duration of intubation for 8016 children ventilated for three or more days, sedated with midazolam (n = 7716) or propofol (n = 300). We matched the propensity scores of 263 pairs of children.
Y, Sasabuchi, H, Yasunaga, H, Matsui, A K, Lefor, K, Fushimi   +4 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Early presentation of postintubation tracheoesophageal fistula: Perioperative anesthetic management

Journal of Anaesthesiology Clinical Pharmacology, 2012
Tracheoesophageal fistula (TEF) in adults occurs as a result of trauma, malignancy, cuff-induced tracheal necrosis from prolonged mechanical ventilation, traumatic endotracheal intubation, foreign body ingestion, prolonged presence of rigid nasogastric ...
Depinder Kaur, Saurabh Anand, Prakash Sharma, Ashwini Kumar   +3 more
doaj   +1 more source

Sedation and its Psychological Effects Following Intensive Care: a Review of the Literature

, 2014
Significant psychological impacts, including post-traumatic stress disorder (PTSD), have been associated with a patients’ under sedation in Intensive Care Units (ICU).
Croxall, Clare, Tyas, Moira, Garside, Joanne   +2 more
core   +1 more source

Prolonged mechanical ventilation as a consequence of acute illness [PDF]

Archives of Disease in Childhood, 1998
To determine why acutely ill children become dependent upon mechanical ventilation and what happens to them.A retrospective medical record study of all patients aged between 1 month and 16 years from 1983 to 1996 who required ventilation for more than 28 days.Forty children were ventilated for between 36 and 180 days before discharge or death.
J, Fraser, T, Henrichsen, Q, Mok, R C, Tasker   +3 more
openaire   +2 more sources