Results 51 to 60 of about 87,591 (293)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Initial respiratory management in preterm infants and bronchopulmonary dysplasia

Clinics, 2011
BACKGROUND: Ventilator injury has been implicated in the pathogenesis of bronchopulmonary dysplasia. Avoiding invasive ventilation could reduce lung injury, and early respiratory management may affect pulmonary outcomes.
Ester Sanz López, Elena Maderuelo Rodríguez, Cristina Ramos Navarro, Manuel Sánchez-Luna   +3 more
doaj   +1 more source

Characteristics and Risk Factors of Children Requiring Prolonged Mechanical Ventilation vs. Non-prolonged Mechanical Ventilation in the PICU: A Prospective Single-Center Study

Frontiers in Pediatrics, 2022
BackgroundProlonged mechanical ventilation (PMV) has become an enormous challenge in intensive care units (ICUs) around the world. Patients treated with PMV are generally in poor health. These patients represent a select cohort with significant morbidity,
Yanling Liu, Yanling Liu, Yanling Liu, Qingyue Wang, Qingyue Wang, Qingyue Wang, Jun Hu, Jun Hu, Jun Hu, Fang Zhou, Fang Zhou, Fang Zhou, Chengjun Liu, Chengjun Liu, Chengjun Liu, Jing Li, Jing Li, Jing Li, Yueqiang Fu, Yueqiang Fu, Yueqiang Fu, Hongxing Dang, Hongxing Dang, Hongxing Dang   +23 more
doaj   +1 more source

Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.

, 2012
CONTEXT: Long-term sedation with midazolam or propofol in intensive care units (ICUs) has serious adverse effects. Dexmedetomidine, an α(2)-agonist available for ICU sedation, may reduce the duration of mechanical ventilation and enhance patient comfort.
Garrat, C, Dexmedetomidine for long term sedation investigators,, Grounds, RM, Sarapohja, T, Ruokonen, Esko, Takala, Jukka, Sarapohja, Toni, Pocock, Stuart J, Ruokonen, E, Jakob, SM, Grounds, R Michael, Pocock, SJ, Garratt, Chris, Bratty, J Raymond, Dexmedetomidine for Long-Term Sedation Investigators, Jakob, Stephan M, Bratty, JR, Takala, J, LAMBERMONT, Bernard, Dexmedetomidine for Long-Term Sedation, Investigators   +19 more
core   +1 more source

Mechanical power density predicts prolonged ventilation following double lung transplantation [PDF]

, 2023
Prolonged mechanical ventilation (PMV) after lung transplantation poses several risks, including higher tracheostomy rates and increased in-hospital mortality.
Michel, Sebastian, Ghiani, Alessandro, Neurohr, Claus, Hinske, Ludwig Christian, Schneider, Christian, Kneidinger, Nikolaus, Irlbeck, Michael, Frank, Sandra   +7 more
core   +1 more source

Prolonged mechanical ventilation and chronic critical illness [PDF]

Journal of Thoracic Disease, 2016
Intensive care medicine has grown effectively in recent decades, parallel to multiple scientific and technological advances of our society. However, patients who survive the initial insult may have significant functional dependency, with slow recovery and high mortality rates (1-3).
Bugedo Tarraza, Guillermo, Egal, Mohamud, Bakker, Jan   +2 more
openaire   +4 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Gender Differences in Prolonged Mechanical Ventilation Patients – A Retrospective Observational Study

International Journal of General Medicine, 2022
Chienhsiu Huang Department of Internal Medicine, Division of Chest Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi County, TaiwanCorrespondence: Chienhsiu Huang, Department of Internal medicine, Division of Chest medicine ...
Huang C
doaj  

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Predictors of Prolonged Mechanical Ventilation after Open Heart Surgery [PDF]

Journal of Cardiovascular and Thoracic Research, 2014
Introduction: Due to the importance of prolonged mechanical ventilation (PMV) as a postoperative complication, predicting "high-risk" patients by identifying predisposing risk factors is of important issue.
Totonchi Ziae, Baazm Farah, Chitsazan Mitra, Seifi Somayeh, Chitsazan Mandana   +4 more
doaj   +1 more source