Results 51 to 60 of about 222,440 (323)

The Long-Term Survival of Successfully Weaned Prolonged Mechanical Ventilation Patients

International Journal of General Medicine, 2020
Background There are rare articles in the literature that addressed long-term survival in successfully weaned prolonged mechanical ventilation patients. How are the long-term outcomes of these successfully weaned prolonged mechanical ventilation patients?
Chienhsiu Huang
semanticscholar   +1 more source

Prolonged mechanical ventilation and chronic critical illness [PDF]

Journal of Thoracic Disease, 2016
Intensive care medicine has grown effectively in recent decades, parallel to multiple scientific and technological advances of our society. However, patients who survive the initial insult may have significant functional dependency, with slow recovery and high mortality rates (1-3).
Bugedo Tarraza, Guillermo, Egal, Mohamud, Bakker, Jan   +2 more
openaire   +4 more sources

Mechanical ventilation induces brainstem inflammation in preterm fetal sheep

Frontiers in Pediatrics, 2023
BackgroundPreterm infants have immature respiratory drive and often require prolonged periods of mechanical ventilation. Prolonged mechanical ventilation induces systemic inflammation resulting in ventilation-induced brain injury, however its effect on ...
Kayla Vidinopoulos, Kayla Vidinopoulos, Zahrah Azman, Zahrah Azman, Ainsley Somers, Ainsley Somers, Valerie A. Zahra, Alison Thiel, Hui Lu, Yen Pham, Nhi Thao Tran, Nhi Thao Tran, Beth J. Allison, Beth J. Allison, Eric Herlenius, Stuart Hooper, Stuart Hooper, Robert Galinsky, Robert Galinsky, Graeme R. Polglase, Graeme R. Polglase   +20 more
doaj   +1 more source

Obstructive Sleep Apnea and Prolonged Mechanical Ventilation [PDF]

Respiratory Care, 2012
Patients with prolonged mechanical ventilation have a high one year mortality, with recognized contributing factors including COPD, cardiac failure, renal failure, and respiratory muscle weakness.[1][1] The study by Diaz-Abad et al[2][2] shows that obstructive sleep apnea (OSA) is very common ...
Johnson, Karin, MD, Johnson, Douglas, MD
openaire   +2 more sources

Analysis of Fluid Balance as Predictor of Length of Assisted Mechanical Ventilation in Children Admitted to Pediatric Intensive Care Unit (PICU)

International Journal of Pediatrics, 2022
Background. Ventilator-associated lung injury (VALI) is a devastating complication of assisted mechanical ventilation (AMV) and is one of the root causes of prolonged AMV. Many strategies were made to decrease the effect of the same.
Praveen Unki, Sushma Save
doaj   +1 more source

Effects of Electrical Muscle Stimulation in Subjects Undergoing Prolonged Mechanical Ventilation

Respiratory care, 2019
BACKGROUND: Muscle atrophy and deconditioning are common complications in patients on prolonged mechanical ventilation (PMV). There are few studies that reviewed the effects of electrical muscle stimulation in this population.
Yen-Huey Chen, Hsiu-Feng Hsiao, Li-Fu Li, N. Chen, Chung-Chi Huang   +4 more
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Association between procalcitonin levels and duration of mechanical ventilation in COVID-19 patients

PLoS ONE, 2020
Background Patients diagnosed with COVID-19 frequently require mechanical ventilation. Knowledge of laboratory tests associated with the prolonged need for mechanical ventilation may guide resource allocation.
Martin Krause, David J. Douin, Timothy T. Tran, Ana Fernandez-Bustamante, Muhammad Aftab, Karsten Bartels, Wenbin Tan   +6 more
doaj   +2 more sources

Patient Transitions Relevant to Individuals Requiring Ongoing Ventilatory Assistance: A Delphi Study

Canadian Respiratory Journal, 2014
BACKGROUND: Various terms, including ‘prolonged mechanical ventilation’ (PMV) and ‘long-term mechanical ventilation’ (LTMV), are used interchangeably to distinguish patient cohorts requiring ventilation, making comparisons and timing of clinical decision
Louise Rose, Robert A Fowler, Roger Goldstein, Sherri Katz, David Leasa, Cheryl Pedersen, Douglas McKim, the CANuVENT Group   +7 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source