Results 31 to 40 of about 143,500 (279)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Effectiveness of multiple versus once-only membrane sweeping at term in preventing prolonged pregnancy: A randomised controlled trial

Scientific African, 2023
Background: Between 4 and 18% of pregnancies are prolonged. Prolonged pregnancy is associated with adverse maternal and perinatal outcomes. Objectives: To compare the effectiveness of once-only versus multiple (weekly) membrane sweeping in reducing the ...
Chidiebere Njoku, James Enimi Omietimi, Peter Chibuzor Oriji, Egbaname Obozegie Samuel Aigere, Stephen Adeniyi Afolabi, Ebiye Serena Tekenah, Akaninyene Eseme Ubom, Panebi Yao Bosrotsi, Oforbuike Samuel Odo   +8 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

ASSESSMENT OF THE PREDISPOSING FACTORS OF PROLONGED PREGNANCY

نشریه پرستاری ایران, 2004
Lengthened pregnancy after the 41st week will create problems for mother, fetus and newborn. Assessment of the predisposing factors of prolonged pregnancy is a research priority.
F Oskouie, KH. Ramezani, S. Taavoni, H. Haghani   +3 more
doaj  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Surgical Management of Foetal Maceration in a Domestic Shorthair Queen

Veterinary Medicine and Science
Foetal maceration is a pregnancy pathology occasionally observed in cats following intrauterine foetal death, characterised by septic decomposition of foetal tissues, resulting in the exposure of foetal bones.
Md. Rubayatul Islam, Rukaiya Mostasin, Md. Sakib Ibna Obaid, Mohammad Raguib Munif   +3 more
doaj   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

Mild Clinical Presentation of Acute Fatty Liver in the Second Trimester of Pregnancy

Case Reports in Obstetrics and Gynecology, 2011
We report a case of 29 years old woman who was diagnosed with acute fatty liver of pregnancy at 23 weeks of gestation with unusual evolution (pregnancy prolonged until 36 weeks of gestation) to draw attention on the possibility of occurrence of this ...
Alaeddine Yassin, Walid Denguezli, Anissa Fessi, Leila Njim, Raja Falah, Abdelfattah Zakhama, Mohamed Sakouhi   +6 more
doaj   +1 more source

Accelerated Progression of Gait Impairment in Parkinson's Disease and REM Sleep Without Atonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with Parkinson's disease (PD) and rapid eye movement (REM) sleep without atonia (RSWA) often have more severe gait disturbances compared to PD without RSWA. The association between the presence and expression of RSWA and the rate of progression of gait impairment in PD is unknown.
Sommer L. Amundsen‐Huffmaster, Jae Woo Chung, Maria E. Linn‐Evans, Matthew N. Petrucci, Chiahao Lu, Destiny J. Weaver, Joshua De Kam, Scott E. Cooper, Paul J. Tuite, Aleksandar Videnovic, Michael J. Howell, Colum D. MacKinnon   +11 more
wiley   +1 more source

Aspectos clínico-epidemiológicos de la inducción del parto en el embarazo postérmino Clinical and epidemiological features of inducing labor in post-term pregnancy

Revista de Ciencias Médicas de Pinar del Río, 2010
El embarazo postérmino es una entidad obstétrica muy discutida en la literatura médica debido a los diferentes criterios empleados con relación al diagnóstico, control prenatal, conducta a tomar y manejo intraparto.
Migdalia de las Mercedes Peña Abraham, Manuel Piloto Morejón, Carlos Romero Díaz, Eddy González Ungo, Marta Valladares Hernández   +4 more
doaj