Results 141 to 150 of about 1,444,780 (246)

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet   +8 more
wiley   +1 more source

Effect of intravenous ondansetron on QT interval prolongation in patients with cardiovascular disease and additional risk factors for torsades: a prospective, observational study

open access: yes, 2011
Matthew J Hafermann1, Rocsanna Namdar2, Gretchen E Seibold2,3, Robert Lee Page 2nd2,31University of Washington Medical Center, Department of Pharmacy, Seattle, WA; 2University of Colorado Anschutz Medical Campus, School of Pharmacy, Aurora, CO ...
Seibold GE   +3 more
core  

Efficient and Accurate Spatio‐Temporal Population Monitoring of Mobile Animals Using Drones and Computer Vision

open access: yesRemote Sensing in Ecology and Conservation, EarlyView.
Drones and computer vision offer an efficient way to estimate animal populations over localized areas, but surveys often require stitching many overlapping images together. If animals move during the survey, traditional orthomosaic‐based counting methods become unreliable, with some animals appearing in multiple locations while others appear not at all,
Benjamin Koger   +5 more
wiley   +1 more source

Prolongation of ventricular depolarization and repolarization in patients with cardiac surgery

open access: yesCorSalud, 2018
Introduction: Cardiac surgery involves a series of aggressive mechanical and chemical elements that affect the cardiac muscle; which may be shown by the electrocardiogram.
Marcelo V. Puga Bravo   +2 more
doaj  

Bioelectronic Wearable Sensors Produced by Computerized Embroidery Using a Dual Thread Approach

open access: yesSmall, EarlyView.
A dual‐thread embroidered SmartBra integrates silver‐plated and conductive‐polymer (PECOTEX) threads to enable simultaneous cardiac monitoring and open‐circuit potentiometric sensing of potassium and sodium in a breast milk substitute. The wearable platform is fabricated using computerized embroidery, offering a scalable, proof‐of‐concept route toward ...
Taliya Weinstein   +9 more
wiley   +1 more source

Photoactivated iridium(III) complexes drive pyroptosis–necroptosis synergy for multi‐network photoimmunotherapy of renal cell carcinoma

open access: yesSmart Molecules, EarlyView.
Photoactivated iridium(III) complexes trigger mitochondrial DNA leakage and Ca²⁺ efflux, simultaneously driving pyroptosis and necroptosis to synergistically enhance immunogenic cell death. This multi‐network cascade promotes dendritic cell maturation and CD8⁺ T cell activation, achieving potent photoimmunotherapy of renal cell carcinoma.
Xin Qin   +16 more
wiley   +1 more source

Inflammatory Shift in Chronic Rhinosinusitis Amidst Guangzhou's Urbanization (2000–2018)

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) exhibits temporal and geographic diversity in pathological endotypes with progressive eosinophilic infiltration, while the underlying causes remain unclear. Current pathological endotypes determination relies on mean cell count per high‐power field, requiring accuracy optimization.
Ning Kang   +16 more
wiley   +1 more source

Association of Cat Sensitization With Comorbid Asthma in Patients With Allergic Rhinitis: A Real‐World Study

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background The prevalence of allergic rhinitis (AR) and asthma (AS) comorbidity (AR + AS) is increasing and is associated with severe allergic symptoms. The impact of cat dander sensitization on AR + AS remains unclear. Methods In this retrospective study, 1154 patients with AR alone and 213 patients with AR + AS were enrolled at the Third ...
Wei‐Hao Wang   +5 more
wiley   +1 more source

ChatGPT Versus DeepSeek in Resectability Categorization of Chronic Rhinosinusitis: A Comparison Based on EPOS 2020

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To evaluate and compare the performance of ChatGPT‐5.5 (2026) and DeepSeek‐V3 (2026) in classifying CRS resectability according to the EPOS 2020 guidelines, employing various prompting strategies. Methods In this retrospective study, 150 chronic rhinosinusitis cases were reviewed, and three rhinology experts classified resectability ...
Jia‐Hong Lao   +8 more
wiley   +1 more source

TriadAuth: Continuous Authentication Through Structured GUI Sequence Modelling With Drift Adaptation and Modality‐Aware Explanations

open access: yesCAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Continuous authentication (CA) systems based on behavioural biometrics are increasingly deployed in zero‐trust architectures, yet their performance degrades over time due to natural behavioural drift arising from device changes, fatigue and evolving habits.
Ahmed Alzahrani
wiley   +1 more source

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