Results 31 to 40 of about 111,832 (326)

QT PRODACT: Usability of Miniature Pigs in Safety Pharmacology Studies: Assessment for Drug-Induced QT Interval Prolongation

Journal of Pharmacological Sciences, 2005
To investigate whether miniature pigs are useful for evaluating the potential of drugs for drug-induced prolongation of the QT interval, we performed an in vivo QT assay using conscious and unrestricted miniature pigs.
Mayumi Kano, Tohru Toyoshi, Sakae Iwasaki, Masami Kato, Masayoshi Shimizu, Takao Ota   +5 more
doaj   +1 more source

QT peak prolongation predicts cardiac death following stroke [PDF]

, 2015
Cardiac death has been linked in many populations to prolongation of the QT interval (QTe). However, basic science research suggested that the best estimate of the time point when repolarisation begins is near the T-wave peak.
Douglas, Denise, Fraser, Hazel W, MacWalter, Ronald S, Ogston, Simon A, Struthers, Allan D, Suich, Joseph, Wong, Kenneth Y K, Wong, Suzanne Y S   +7 more
core   +1 more source

Pharmacogenetics of Drug-Induced QT Interval Prolongation: An Update [PDF]

, 2015
A prolonged QT interval is an important risk factor for ventricular arrhythmias and sudden cardiac death. QT prolongation can be caused by drugs. There are multiple risk factors for drug-induced QT prolongation, including genetic variation.
Berg, M.E. (Marten) van den, Eijgelsheim, M. (Mark), Niemeijer, M.N. (Maartje), Rijnbeek, P.R. (Peter), Stricker, B.H.Ch. (Bruno)   +4 more
core   +1 more source

Trigger versus Substrate: Multi-Dimensional Modulation of QT-Prolongation Associated Arrhythmic Dynamics by a hERG Channel Activator [PDF]

, 2017
Background: Prolongation of the QT interval of the electrocardiogram (ECG), underlain by prolongation of the action potential duration (APD) at the cellular level, is linked to increased vulnerability to cardiac arrhythmia.
Antzelevitch, Antzelevitch, Benson, Benson, Benson, Benson, Bezekci, Bilet, Bohnen, Camm, Campos, Clancy, Clayton, Clusin, Colman, Colman, Drouin, Dutta, Glukhov, Grunnet, Guo, Hansen, Hart, Janse, Kalin, Kléber, Kumar, Lankipalli, Li, Lou, Mann, Mirams, Moss, Nachimuthu, Noble, Němec, O'Hara, Pandit, Peitersen, Perez Alday, Perez Alday, Perez Alday, Ratner, Restrepo, Rush, Schwartz, Shaw, Smaill, Starmer, Strom, ten Tusscher, Tomaselli, Tse, Venetucci, Vinet, Wagner, Walton, Wu   +57 more
core   +2 more sources

QT PRODACT: In Vivo QT Assay in Anesthetized Dog for Detecting the Potential for QT Interval Prolongation by Human Pharmaceuticals

Journal of Pharmacological Sciences, 2005
The purpose of this study was to assess the utility of the isoflurane-anesthetized dog model for detecting the potential for QT interval prolongation by human pharmaceuticals.
Hiroyuki Tashibu, Hiroyasu Miyazaki, Kumiko Aoki, Yasuki Akie, Keiji Yamamoto   +4 more
doaj   +1 more source

Acquired long QT syndrome in chronic kidney disease patients

Renal Failure, 2020
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients. QT interval prolongation is a congenital or acquired condition that is associated with an increased risk of torsade de pointes (TdP ...
Peng Liu, Lu Wang, Dan Han, Chaofeng Sun, Xiaolin Xue, Guoliang Li   +5 more
doaj   +1 more source

QT is longer in drug-free patients with schizophrenia compared with age-matched healthy subjects. [PDF]

PLoS ONE, 2014
The potassium voltage-gated channel KCNH2 is a well-known gene in which mutations induce familial QT interval prolongation. KCNH2 is suggested to be a risk gene for schizophrenia.
Kumiko Fujii, Yuji Ozeki, Hiroaki Okayasu, Yumiko Takano, Takahiro Shinozaki, Hiroaki Hori, Masami Orui, Minoru Horie, Hiroshi Kunugi, Kazutaka Shimoda   +9 more
doaj   +1 more source

Measurement and interpretation of electrocardiographic QT intervals in murine hearts. [PDF]

, 2014
Alterations in ECG QT intervals correlate with the risk of potentially fatal arrhythmias, for which transgenic murine hearts are becoming increasingly useful experimental models. However, QT intervals are poorly defined in murine ECGs.
Fraser, James A, Huang, Christopher L-H, King, James H, Wu, JingJing, Zhang, Yanmin   +4 more
core   +2 more sources

Use of QT intervals for a more accurate diagnose of syncope and evaluation of syncope severity. [PDF]

, 2014
BACKGROUND: This study aimed to evaluate the use of QT intervals, their diagnostic predictive value in patients with syncope and their relationship with syncope severity.
BUTTA', Carmelo, CANINO, Baldassare, CASUCCIO, Alessandra, DI RAIMONDO, Domenico, GIARRUSSO, Lucia, Licata, G, Lo Vecchio, S, Miceli, G, PINTO, Antonio, TUTTOLOMONDO, Antonino   +9 more
core   +1 more source

Corrected QT interval and QT dispersion in temporal lobe epilepsy

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2021
Background Cardiac arrhythmias are expected among patients with epilepsy due to the effect of anti-epileptic drugs. Temporal lobe epilepsy also causes autonomic seizures that may affect heart rhythm.
Maram Samy Nasef, Ahmed Abdelmonem Gaber, Yousry Aboelnaga Abdelhamid, Islam Bastawy, Salem Taha Abdelhady, Mona Mokhtar Wahid el din   +5 more
doaj   +1 more source