Results 11 to 20 of about 53,127 (203)

Prolonged QT Interval: A Tricky Diagnosis? [PDF]

The American Journal of Cardiology, 1997
Prolonged heart-rate adjusted QT intervals on the electrocardiogram (ECG) are associated with an increased risk for coronary heart disease and sudden death. However, the diagnosis of the prolonged QT interval is hampered by lack of standards. We studied variations in the prevalence of prolonged QT, based on different common definitions, in a large ...
M C, de Bruyne, A W, Hoes, J A, Kors, J M, Dekker, A, Hofman, J H, van Bemmel, D E, Grobbee   +6 more
openaire   +5 more sources

The relation between QT interval and T-wave variables in hypertensive patients

Journal of Pharmacy and Bioallied Sciences, 2011
Background : The standard 12-lead ECG (electrocardiogram) continues to be the most frequently recorded noninvasive test in medicine. A prolonged ECG QT interval and Tpeak-Tend (Tpe) interval are predictors of ventricular arrhythmia and sudden cardiac ...
Ioana Mozos, Corina Serban
doaj   +1 more source

QT Interval Changes in Moderate and Severe Brain Injuries [PDF]

, 2012
Backgrounds: Traumatic brain injuries are common mortality causes in many countries. Electrocardiogram (ECG) changes after brain injuries are known, and among them alteration of QT interval is common.
Abbasi Fard, Salman., Abrishamkar, Saied., Irii, Abdol_Razagh., Momeni, Ali., Rohanizadegan, Mersedeh.   +4 more
core   +1 more source

QT PRODACT: Usability of Miniature Pigs in Safety Pharmacology Studies: Assessment for Drug-Induced QT Interval Prolongation

Journal of Pharmacological Sciences, 2005
To investigate whether miniature pigs are useful for evaluating the potential of drugs for drug-induced prolongation of the QT interval, we performed an in vivo QT assay using conscious and unrestricted miniature pigs.
Mayumi Kano, Tohru Toyoshi, Sakae Iwasaki, Masami Kato, Masayoshi Shimizu, Takao Ota   +5 more
doaj   +1 more source

QT peak prolongation predicts cardiac death following stroke [PDF]

, 2015
Cardiac death has been linked in many populations to prolongation of the QT interval (QTe). However, basic science research suggested that the best estimate of the time point when repolarisation begins is near the T-wave peak.
Douglas, Denise, Fraser, Hazel W, MacWalter, Ronald S, Ogston, Simon A, Struthers, Allan D, Suich, Joseph, Wong, Kenneth Y K, Wong, Suzanne Y S   +7 more
core   +1 more source

Prolonged QT interval in Rett syndrome [PDF]

Archives of Disease in Childhood, 1999
Rett syndrome is a severe neurodevelopmental disorder of unknown aetiology. A prolonged QT interval has been described previously in patients with Rett syndrome. To investigate QT prolongation and the presence of cardiac tachyarrhythmias in Rett syndrome electrocardiography and 24 hour Holter monitoring were performed prospectively in a cohort of 34 ...
C J, Ellaway, G, Sholler, H, Leonard, J, Christodoulou   +3 more
openaire   +2 more sources

Pharmacogenetics of Drug-Induced QT Interval Prolongation: An Update [PDF]

, 2015
A prolonged QT interval is an important risk factor for ventricular arrhythmias and sudden cardiac death. QT prolongation can be caused by drugs. There are multiple risk factors for drug-induced QT prolongation, including genetic variation.
Berg, M.E. (Marten) van den, Eijgelsheim, M. (Mark), Niemeijer, M.N. (Maartje), Rijnbeek, P.R. (Peter), Stricker, B.H.Ch. (Bruno)   +4 more
core   +1 more source

Trigger versus Substrate: Multi-Dimensional Modulation of QT-Prolongation Associated Arrhythmic Dynamics by a hERG Channel Activator [PDF]

, 2017
Background: Prolongation of the QT interval of the electrocardiogram (ECG), underlain by prolongation of the action potential duration (APD) at the cellular level, is linked to increased vulnerability to cardiac arrhythmia.
Antzelevitch, Antzelevitch, Benson, Benson, Benson, Benson, Bezekci, Bilet, Bohnen, Camm, Campos, Clancy, Clayton, Clusin, Colman, Colman, Drouin, Dutta, Glukhov, Grunnet, Guo, Hansen, Hart, Janse, Kalin, Kléber, Kumar, Lankipalli, Li, Lou, Mann, Mirams, Moss, Nachimuthu, Noble, Němec, O'Hara, Pandit, Peitersen, Perez Alday, Perez Alday, Perez Alday, Ratner, Restrepo, Rush, Schwartz, Shaw, Smaill, Starmer, Strom, ten Tusscher, Tomaselli, Tse, Venetucci, Vinet, Wagner, Walton, Wu   +57 more
core   +2 more sources

QT PRODACT: In Vivo QT Assay in Anesthetized Dog for Detecting the Potential for QT Interval Prolongation by Human Pharmaceuticals

Journal of Pharmacological Sciences, 2005
The purpose of this study was to assess the utility of the isoflurane-anesthetized dog model for detecting the potential for QT interval prolongation by human pharmaceuticals.
Hiroyuki Tashibu, Hiroyasu Miyazaki, Kumiko Aoki, Yasuki Akie, Keiji Yamamoto   +4 more
doaj   +1 more source

Acquired long QT syndrome in chronic kidney disease patients

Renal Failure, 2020
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients. QT interval prolongation is a congenital or acquired condition that is associated with an increased risk of torsade de pointes (TdP ...
Peng Liu, Lu Wang, Dan Han, Chaofeng Sun, Xiaolin Xue, Guoliang Li   +5 more
doaj   +1 more source