Results 1 to 10 of about 708 (69)

Prolongation of the QT interval under treatment with hydroxychloroquine in a patient with systemic lupus erythematosus: A case report [PDF]

Romanian Journal of Rheumatology, 2022
Hydroxychloroquine (HCQ) is an antimalarial used in the treatment of patients with systemic lupus erythematosus (SLE). HCQ has a good safety profile and favorable results in terms of controlling clinical manifestations in SLE.
Ioan-Teodor Dragoi, Alexandra Maria Burlui, Luana Macovei, Patricia Richter, Elena Rezus   +4 more
doaj   +1 more source

Prolonged QT Interval in Cirrhosis: Twisting Time?

Gut and Liver, 2022
Approximately 30% to 70% of patients with cirrhosis have QT interval prolongation. In patients without cirrhosis, QT prolongation is associated with an increased risk of ventricular arrhythmias, such as torsade de pointes (TdP).
William Lee, Bert Vandenberk, Satish R. Raj, Samuel S. Lee   +3 more
doaj   +1 more source

Estimation of cardiac QTc intervals in people prescribed antipsychotics: a comparison of correction factors

Therapeutic Advances in Psychopharmacology, 2022
Background: A prolonged electrocardiogram (ECG) QT interval is associated with cardiac events and increased mortality. Antipsychotics can prolong the QT interval.
Teodora Andric, Karl Winckel, Timothy David Tanzer, Samantha Hollingworth, Lesley Smith, Katherine Isoardi, Olivier Tan, Dan Siskind   +7 more
doaj   +1 more source

Prevalence of QTc interval prolongation and its associated risk factors among psychiatric patients: a prospective observational study

BMC Psychiatry, 2020
Background QT interval prolongation is a growing concern worldwide, posing psychiatric patients to life-threatening fatal arrhythmias i.e., torsade de pointes.
Zahid Ali, Mohammad Ismail, Zahid Nazar, Fahadullah Khan, Qasim Khan, Sidra Noor   +5 more
doaj   +1 more source

Screening for QT Prolongation in the Emergency Department: Is There a Better “Rule of Thumb?”

Western Journal of Emergency Medicine, 2020
Introduction: Identification of QT prolongation in the emergency department (ED) is critical for appropriate monitoring, disposition, and treatment of patients at risk for torsades de pointes (TdP).
Megan L. Rischall, Stephen W. Smith, Ari B. Friedman   +2 more
doaj   +1 more source

Incident prolonged QT interval in midlife and late-life cognitive performance.

PLoS ONE, 2020
BackgroundMeasures of cardiac ventricular electrophysiology have been associated with cognitive performance in cross-sectional studies. We sought to evaluate the association of worsening ventricular repolarization in midlife, as measured by incident ...
Claudia K Suemoto, Laura E Gibbons, Evan L Thacker, Jonathan D Jackson, Claudia L Satizabal, Brianne M Bettcher, Lenore Launer, Caroline Phillips, Lon R White, Melinda C Power   +9 more
doaj   +1 more source

The relation between QT interval and T-wave variables in hypertensive patients

Journal of Pharmacy and Bioallied Sciences, 2011
Background : The standard 12-lead ECG (electrocardiogram) continues to be the most frequently recorded noninvasive test in medicine. A prolonged ECG QT interval and Tpeak-Tend (Tpe) interval are predictors of ventricular arrhythmia and sudden cardiac ...
Ioana Mozos, Corina Serban
doaj   +1 more source

Prolonged QT Interval in a Patient With Coronavirus Disease-2019: Beyond Hydroxychloroquine and Azithromycin

Journal of Investigative Medicine High Impact Case Reports, 2020
Recent reports have suggested an increased risk of QT prolongation and subsequent life-threatening ventricular arrhythmias, particularly torsade de pointes, in patients with coronavirus disease-2019 (COVID-19) treated with hydroxychloroquine and ...
B K Anupama MBBS, Soumya Adhikari MBBS, Debanik Chaudhuri MD   +2 more
doaj   +1 more source

QT PRODACT: Usability of Miniature Pigs in Safety Pharmacology Studies: Assessment for Drug-Induced QT Interval Prolongation

Journal of Pharmacological Sciences, 2005
To investigate whether miniature pigs are useful for evaluating the potential of drugs for drug-induced prolongation of the QT interval, we performed an in vivo QT assay using conscious and unrestricted miniature pigs.
Mayumi Kano, Tohru Toyoshi, Sakae Iwasaki, Masami Kato, Masayoshi Shimizu, Takao Ota   +5 more
doaj   +1 more source

QT PRODACT: In Vivo QT Assay in Anesthetized Dog for Detecting the Potential for QT Interval Prolongation by Human Pharmaceuticals

Journal of Pharmacological Sciences, 2005
The purpose of this study was to assess the utility of the isoflurane-anesthetized dog model for detecting the potential for QT interval prolongation by human pharmaceuticals.
Hiroyuki Tashibu, Hiroyasu Miyazaki, Kumiko Aoki, Yasuki Akie, Keiji Yamamoto   +4 more
doaj   +1 more source