Results 141 to 150 of about 902 (153)

The prolyl oligopeptidase and α-synuclein connection revisited

Biochimie
The aim of this work was to revisit the connection between prolyl oligopeptidase (PREP) and α-synuclein (aSyn) by presenting novel data from cell free and cellular assays and to discuss the results in a contemporary context. The aSyn aggregation process was studied using fluorescence correlation spectroscopy and thioflavin-T fluorescence. Binding sites
Roos Van Elzen, Yannick Waumans, Sangeeta Nath, Pieter Van der Veken, Sonja Kerkhoff, Evert Van Dijk, Markus Morawski, Steffen Roßner, Yves Engelborghs, Ingrid De Meester, Anne-Marie Lambeir   +10 more
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Search for substrates for prolyl oligopeptidase in porcine brain

Peptides, 2005
The function of prolyl oligopeptidase (PO) has been associated with several disorders of the central nervous system. The purpose of this study was to identify endogenous substrates for recombinant porcine PO in porcine brain. The smaller polypeptides were extracted from total brain homogenates and fractionated by two-dimensional chromatography prior to
Brandt, Inger, de Vriendt, Kris, Devreese, Bart, van Beeumen, Jozef, van Dongen, Walter, Augustyns, Koen, De Meester, Ingrid, Scharpe, Simon, Lambeir, Anne-Marie   +8 more
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Dicarboxylic Acidbis(l-Prolyl-pyrrolidine) Amides as Prolyl Oligopeptidase Inhibitors

Journal of Medicinal Chemistry, 2002
New dicarboxylic acid bis(L-prolyl-pyrrolidine) amides were synthesized, and their inhibitory activity against prolyl oligopeptidase from pig brain was tested in vitro. As compared with earlier described prolyl oligopeptidase inhibitors, these new compounds have in common an L-prolyl-pyrrolidine moiety, but the typical lipophilic acyl end group is ...
Erik A A, Wallén, Johannes A M, Christiaans, Markus M, Forsberg, Jarkko I, Venäläinen, Pekka T, Männistö, Jukka, Gynther   +5 more
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Conformationally rigid N-acyl-5-alkyl-l-prolyl-pyrrolidines as prolyl oligopeptidase inhibitors

Bioorganic & Medicinal Chemistry, 2003
In the N-acyl-L-prolyl-pyrrolidine type of prolyl oligopeptidase inhibitors the L-prolyl group was replaced by different 5-alkyl-L-prolyl groups, resulting in a series of N-acyl-5-alkyl-L-prolyl-pyrrolidines. Since N-amides of 5-alkyl-L-prolines are conformationally more rigid than those of L-proline, the main objective was to make more rigid prolyl ...
Erik A A, Wallén, Johannes A M, Christiaans, Taija J, Saarinen, Elina M, Jarho, Markus M, Forsberg, Jarkko I, Venäläinen, Pekka T, Männistö, Jukka, Gynther   +7 more
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Inhibition of Prolyl Oligopeptidase by Fmoc‐Aminoacylpyrrolidine‐2‐Nitriles

Journal of Neurochemistry, 1996
Abstract: Prolyl oligopeptidase (EC 3.4.21.26), a widely distributed cytosolic enzyme, cleaves peptidylprolyl peptide and peptidylprolyl amino acid bonds in many neuropeptide substrates. Its action on vasopressin has been proposed as the underlying mechanism accounting for the ability of inhibitors of prolyl oligopeptidase to reverse scopolamine ...
J, Li, E, Wilk, S, Wilk
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Association of Prolyl Oligopeptidase with Conventional Neurotransmitters in the Brain

CNS & Neurological Disorders - Drug Targets, 2011
Prolyl oligopeptidase (POP), is an 80-kDa serine protease that hydrolyzes peptides smaller than 30-mer at the carboxyl side of an internal proline-residue. POP is commonly believed to cleave a number of neuropeptides claimed to be involved in learning, memory and mood.
Peltonen Iida, Männistö Pekka, Myöhänen Timo Tapio   +2 more
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Interaction of prolyl oligopeptidase with α-synuclein.

CNS & neurological disorders drug targets, 2012
Prolyl oligopeptidase (PO) interacts with α-syncline in vitro. It is a weak interaction that induces a nucleation prone conformation of α-synuclein. PO accelerates aggregation and fibril formation of α-syncline in a process that can be reversed by specific inhibitors and is also influenced by an impairing mutation in the PO active site.
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Prolyl Oligopeptidase

2013
Kiyoshi Ito, Yoshitaka Nakajima, Tadashi Yoshimoto   +2 more
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Prolyl oligopeptidases.

Methods in enzymology, 1995
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STRUCTURAL STUDIES OF Trypanosoma brucei PROLYL OLIGOPEPTIDASE

2008
M M Lima, Bastos, Izabela M. D., Neves, David, F J Medrano, Barbosa, João Alexandre Ribeiro Gonçalves, Freitas, Sonia Maria De, Santana, Jaime M   +6 more
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