Results 51 to 60 of about 2,967 (149)
Toxicological analyses of the bone matrix: Successes and challenges
Archaeometry, Volume 67, Issue 4, Page 1001-1021, August 2025.Abstract This study aimed to conduct an in‐depth and systematic literature review dealing with toxicological analyses on human bone tissue and focusing on the forensic toxicological and archaeotoxicological field. Several studies have focused their research on medical drugs, drugs of abuse, and trace elements on both human cadavers and skeletal remains,
Gaia Giordano +3 more
wiley +1 more source
Epilepsia Open, Volume 10, Issue 2, Page 593-601, April 2025.Abstract Protein‐activated kinases mediate spine morphogenesis and synaptic plasticity. PAK3 is part of the p21‐activated kinases (PAKs) family of Ras‐signaling serine/threonine kinases. Pathogenic variants in the X‐linked gene PAK3 have been described in patients with neurodevelopmental syndromes.
Antonio Gambardella +12 more
wiley +1 more source
Brain and Behavior, Volume 15, Issue 3, March 2025.Using ciPLV, an EEG connectivity metric less affected by volume conduction, we found that schizophrenia patients exhibit distinct long‐range functional connectivity abnormalities in theta and beta/gamma bands—suggesting new potential biomarkers for chronic schizophrenia.
Christophe Domingos +7 more
wiley +1 more source
European Journal of Neurology, Volume 32, Issue 1, January 2025.Abstract Background and purpose Behavioral variant frontotemporal dementia (bvFTD) is essentially characterized by progressive changes in personality and cognition. Clinically, bvFTD presents with often profound behavioral symptomatology. Despite the high burden of these symptoms for both patients and caregivers, there is no general consensus on an ...
Dirk van Paassen +6 more
wiley +1 more source
JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 7, Issue 12, Page 1207-1227, December 2024.Abstract Cognitive impairment affects around 19% of community‐dwelling older adults in the United States. Pharmacists can play a significant role in identifying and deprescribing cognitive‐impairing medications through cognitive‐focused medication reviews or as part of comprehensive medication management.
Jacob Stanton +4 more
wiley +1 more source
Безопасность и риск фармакотерапииINTRODUCTION. The high risk of life-threatening ventricular arrhythmias, particularly Torsade de Pointes (TdP), makes QT prolongation one of the most significant adverse drug reactions (ADRs) due to cardiotoxicity associated with antipsychotics (APs).AIM.
R. F. Nasyrova +3 more
doaj +1 more source
A Detailed Evaluation of Promazine Metabolism.
Experimental Biology and Medicine, 1964 SummaryThin-layer and paper chroma-tography have been used to study the metabolism of promazine following its oral administration to man and animals. Humans excrete about 33% of the drug in urine, in the form of 26-30 derivatives. These compounds are distributed between nonphenolic (14%) and phenolic (19%) fractions in the ratio of 1 to 1.4.
H, GOLDENBERG +3 more
openaire +2 more sources
Metabolism and excretion of promazine by the horse
Journal of Pharmacy and Pharmacology, 1969 AbstractThe urinary excretion of promazine and its metabolites has been examined in five horses, by ultraviolet spectrometry and thin-layer chromatography. In each horse, excretion continued for at least 96 h although the amount excreted was low, being about 11% of the dose. No correlation of excretion and pH or urinary volume was observed.
J J, Weir, J, Sanford
openaire +2 more sources
Determination of Retention Behavior and p<i>K</i> <sub>a</sub> Values of Some Phenothiazines with Green Chemistry Approach. [PDF]
ACS OmegaÖztürk Z +2 more
europepmc +1 more source