Results 61 to 70 of about 12,284 (241)
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Thermal instability in coronal loops: Linking eigenvalue spectra to time-dependent evolution
Astronomy & AstrophysicsContext. Cool, dense condensations such as coronal rain and prominences suggest that coronal plasma can undergo runaway radiative cooling. Connecting this behaviour to linear thermal modes requires a fuller understanding of the deeper connection between ...
Kelly Adrian +2 more
doaj +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Dynamics, thermodynamics, and fine structure of virtual erupting filaments
Astronomy & AstrophysicsContext. It is not fully understood why some solar filaments erupt, whereas others do not. Filaments that erupt typically undergo a slow rise, followed by an acceleration phase; this transition requires further investigation.
Donné D. +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Non-linear force-free magnetic dip models of quiescent prominence fine structures [PDF]
, 2013 S.G. and P.H. acknowledge the support from grant 209/12/0906 of the Grant Agency of the Czech Republic. P.H. acknowledges the support from grant P209/10/1680 of the Grant Agency of the Czech Republic. S.G. and P.H.
Mackay, D. +11 more
core +1 more source
Handheld Osteotomes Facilitate Arthroscopic Elbow Osteophyte Removal
Arthroscopy Techniques, 2018 Arthroscopic elbow surgery is a challenging procedure in part because of the limited intra-articular volume of the joint, the congruence of the elbow articulation, and the close proximity of the neurovascular structures.
Wesley S. Greer, M.D. +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Living Reviews in Solar Physics, 2012 Prominences are intriguing, but poorly understood, magnetic structures of the solar corona. The dynamics of solar prominences has been the subject of a large number of studies, and of particular interest is the study of prominence oscillations.
Iñigo Arregui +2 more
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source