Results 81 to 90 of about 22,877 (292)

Magnetic field in atypical prominence structures: Bubble, tornado and eruption [PDF]

open access: yes, 2016
Spectropolarimetric observations of prominences have been obtained with the THEMIS telescope during four years of coordinated campaigns. Our aim is now to understand the conditions of the cool plasma and magnetism in `atypical' prominences, namely when ...
Ariste, A. López   +5 more
core   +4 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Prominence Oscillations

open access: yesLiving Reviews in Solar Physics, 2012
Prominences are intriguing, but poorly understood, magnetic structures of the solar corona. The dynamics of solar prominences has been the subject of a large number of studies, and of particular interest is the study of prominence oscillations.
Iñigo Arregui   +2 more
doaj  

Non-thermal line-broadening in solar prominence [PDF]

open access: yes, 2015
We show that the line broadening in quiescent solar prominences is mainly due to non-thermal velocities. We have simultaneously observed a wide range of optically thin lines in quiescent prominences, selected for bright and narrow Mg\,b emission without ...
Stellmacher, Goetz, Wiehr, Eberhard
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

The magnetic field of solar prominences

open access: yes, 2008
In his famous monographs, Einar Tandberg-Hanssen writes that "the single, physically most important parameter to study in prominences may be the magnetic field.
Paletou, F.
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Doppler imaging an X-ray flare on the ultrafast rotator BO Mic - A contemporaneous multiwavelength study using XMM-Newton and VLT [PDF]

open access: yes, 2007
We present an analysis of contemporaneous photospheric, chromospheric and coronal structures on the highly active K-dwarf star BO Mic (Speedy Mic).
Barnes   +19 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Re-visiting the embryogenesis of the human lower lip: An overlooked paradigm

open access: yesFrontiers in Physiology, 2012
The rare opportunity to study a human fetus showing bilateral clefting of the lower lip along with other associated anomalies resembling those of the equally rare Pena-Shokeir phenotype prompts this report.
Heleni eVastardis   +3 more
doaj   +1 more source

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