Results 101 to 110 of about 22,877 (292)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Images in Medicine of Davener’s Dermatosis: Frictional Hyperpigmentation of the Spine [PDF]

Journal of Clinical and Diagnostic Research
Friction-induced dermatoses are a distinct group of skin conditions resulting from chronic mechanical pressure or repetitive trauma over bony prominences.
Narala Sai Akankssha, Sree Divya Mohan, Ramya Ramanathan   +2 more
doaj   +1 more source

Prominence Seismology [PDF]

Proceedings of the International Astronomical Union, 2013
AbstractQuiescent solar prominences are cool and dense plasma clouds located inside the hot and less dense solar corona. They are highly dynamic structures displaying flows, instabilities, oscillatory motions, etc. The oscillations have been mostly interpreted in terms of magnetohydrodynamic (MHD) waves, which has allowed to perform prominence ...
openaire   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

On the structure and evolution of a polar crown prominence/filament system

, 2014
Polar crown prominences are made of chromospheric plasma partially circling the Suns poles between 60 and 70 degree latitude. We aim to diagnose the 3D dynamics of a polar crown prominence using high cadence EUV images from the Solar Dynamics Observatory
A.A. van Ballegooijen, A.M. Vásquez, B. Schmieder, B. Schmieder, B.C. Low, B.C. Low, C.R. DeVore, D.F. Webb, D.H. Mackay, D.H. Mackay, D.H. Mackay, D.H. Mackay, D.J. Schmit, D.J. Schmit, E.R. Priest, G. Aulanier, G. Aulanier, G. Del Zanna, H. Wang, H.R. Gilbert, H.S. Hudson, J. Chae, J. Chae, J. Dudík, J. Schou, J.B. Zirker, J.L. Leroy, J.R. Lemen, J.W. Harvey, L. Li, L.A. Rachmeler, M. Kuperus, M. Kuperus, M. Minarovjech, N. Labrosse, N.K. Panesar, P. Heinzel, P. Heinzel, P. Heinzel, P.C. Martens, P.S. McIntosh, R.A. Howard, R.B. Dahlburg, S. Parenti, S. Régnier, S.E. Gibson, S.E. Gibson, S.E. Gibson, S.F. Martin, S.F. Martin, S.K. Antiochos, S.R. Habbal, T. Berger, T. Hirayama, T.A. Kucera, T.A. Kucera, T.E. Berger, T.E. Berger, U. Anzer, U. Anzer, U. Ba̧k-Stȩślicka, V. Gaizauskas, Y. Lin, Y. Su, Y.M. Wang   +64 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

An approach to psoriasis in general practice

South African Family Practice, 2012
Psoriasis is a genetically determined inflammatory and proliferative disease of the skin, presenting with sharply demarcated scaly plaques, especially on the extensor prominences and the scalp.
M.H. Motswaledi, L. Nkosi
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source